The protective effect of sildenafil on liver sinusoidal obstructive syndrome after oxaliplatin-based chemotherapy: An experimental animal study

Mustafa Taner Bostancı; İbrahim Yılmaz; Mehmet Saydam; Hakan Uzunoğlu; Gülden Aydog; Koray Koşmaz; Erdal Bostancı

doi:10.28982/josam.679489

Authors

Mustafa Taner Bostancı https://orcid.org/0000-0003-2876-2683
İbrahim Yılmaz https://orcid.org/0000-0003-0759-0974
Mehmet Saydam https://orcid.org/0000-0003-0953-4589
Hakan Uzunoğlu https://orcid.org/0000-0002-6742-8103
Gülden Aydog https://orcid.org/0000-0002-7009-751X
Koray Koşmaz Ministry of Health, Ankara City Hospital, Department of Gastroenterological Surgery, Ankara, Turkey https://orcid.org/0000-0003-2111-3162
Erdal Bostancı https://orcid.org/0000-0002-0663-0156

DOI:

https://doi.org/10.28982/josam.679489

Keywords:

Oxaliplatin, Sinusoidal obstructive syndrome, Sildenafil, Colorectal cancer, Liver metastasis

Abstract

Aim: Sinusoidal obstructive syndrome (SOS) that develops due to oxaliplatin-based chemotherapy influences morbidity and mortality following surgical treatment of colorectal liver metastases. The aim of this study was to evaluate the protective effect of sildenafil on liver damage (sinusoidal obstructive syndrome (SOS)) that develops due to oxaliplatin-based chemotherapy.
Methods: An experimental animal study was conducted and a total of 42 rats were randomly separated into 4 groups as Sham, intraperitoneal chemotherapy (ipCT), ipCT+low-dose sildenafil treatment, and ipCT +high-dose sildenafil treatment. The ipCT was applied once a week for 5 weeks. Histochemical analysis was made in the livers removed from rats.
Results: Parenchymal, stromal, and vascular changes were examined, and no statistically significant difference was determined between the groups with respect to the severity of sinusoidal dilatation (P=0.243). The groups significantly differed with regards to centrilobular, peliotic changes and hepatocellular changes (P<0.001).
Conclusion: Sildenafil has a protective effect against liver damage that develops due to oxaliplatin-based chemotherapy and prevents the development of SOS during chemotherapy in colorectal cancer patients. Therefore, it could be considered as a treatment strategy.

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