Retinal nerve fiber layer thickness in patients with essential tremor and Parkinson’s disease

Halit Fidancı; Nevra Öksüz; Şeyda Özal; Ufuk Adıgüzel; Şükrü Kaleağası; Okan Doğu

doi:10.28982/josam.661757

Authors

Halit Fidancı https://orcid.org/0000-0001-6573-9090
Nevra Öksüz https://orcid.org/0000-0003-4825-7457
Şeyda Özal https://orcid.org/0000-0001-5105-5800
Ufuk Adıgüzel https://orcid.org/0000-0001-6618-1359
Şükrü Kaleağası https://orcid.org/0000-0003-2709-3051
Okan Doğu https://orcid.org/0000-0002-2126-9792

DOI:

https://doi.org/10.28982/josam.661757

Keywords:

Parkinson’s disease, Essential tremor, Optical coherence tomography, Retinal nerve fiber layer

Abstract

Aim: Essential tremor (ET) and Parkinson’s disease (PD) are common movement disorders. In PD, visual problems such as impaired color vision and decreased visual acuity have been reported. Studies have shown that retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) is decreased in PD and some neurodegenerative diseases. Due to the similarities of ET and PD, we aimed to evaluate RNFL measured by OCT in ET and PD patients.

Methods: PD, ET and control groups were formed in this prospective case-control study. Each group included 30 individuals, and 180 eyes were examined. In these groups, RNFL quadrants, macula and fovea were evaluated with OCT. In the ET group, tremor severity was included in the analyses. The severity of disease in PD was assessed with the Unified Parkinson's Disease Rating scale and the Hoehn and Yahr scale.

Results: In the control, ET and PD groups, the mean RNFL thicknesses of the right eye were 93.2 (8.1), 86.7 (9.7), 86.8 (10.2) μm, respectively. These values were lower in the PD and ET groups compared to the control group (P=0.026, P=0.025). There was no correlation between disease severity and RNFL thickness in ET.

Conclusion: Decreased RNFL thickness in ET may indicate that ET is a neurodegenerative disease, such as PD. There may be subclinical retinal impairment in ET.

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