Investigation of SCUBE-1 levels in pediatric patients with beta-thalassemia




Beta-thalassemia major, Children, SCUBE-1, Thrombosis


Aim: A thrombosis and inflammation marker, Signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth factor)-like domain-containing protein 1 (SCUBE-1) is expressed in endothelial cells and activated platelets. We aimed to investigate the levels of this marker in patients with Thalassemia major (TM), a disease which causes a tendency to thrombosis.

Methods: Twenty patients with TM and age and gender-matched twenty healthy controls were included in this prospective case-control study. Other thrombosis markers such as D-dimer and homocysteine were studied in addition to SCUBE-1 in both groups.

Results: The SCUBE1 and D-dimer levels were higher in the TM group compared to the control group (P=0.004, P=0.023, respectively). A significant positive correlation was detected between platelet count and SCUBE1 (r=0.342, P=0.031).

Conclusion: We detected elevated SCUBE1 levels in children with TM compared to the healthy controls, which correlated with platelet count. SCUBE1 may be used as a thrombosis marker in TM in the early stages of the disease.


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Research Article

How to Cite

Acıpayam C, Tuncel DA, Güneş H, Seringeç Akkeçeci BN, İnanç Tolun F, İpek S, Duyuran Ömer. Investigation of SCUBE-1 levels in pediatric patients with beta-thalassemia. J Surg Med [Internet]. 2019 Dec. 3 [cited 2022 Jun. 25];3(12):825-8. Available from:

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