Effect of cardiac rehabilitation on mortality related inflammatory markers



Cardiac rehabilitation, Inflammation, Mortality


Aim: Cardiac Rehabilitation (CR) is a rehabilitation method which decreases mortality in cardiac patients. The main goal of this study is to investigate the effect of CR on neutrophil-to-lymphocyte ratio (NLR) and thrombocyte-to-lymphocyte ratio (TLR), which are inflammatory markers directly related to mortality in cardiac patients. The secondary goal is to assess the effect of CR on functional capacity.

Methods: This retrospective cohort study consists of 211 CR patients who completed 30 sessions of tailored comprehensive CR programs. Their functional status and cardiovascular endurance were assessed with a 6- minute walk test and a cycle ergometer test. Inflammatory markers (TLR, NLR, sedimentation, CRP) were obtained from blood testing and demographic data were collected. After 30 sessions of CR all tests were repeated. No adverse events occurred during the exercise sessions.

Results: Among 211 patients enrolled in this the study, 114 (%54) were female and 97 (%46) were male. Mean age was 56.28 (10.25) years (min 21 - max 81 years). 94 (%44.5) patients were hypertensive, 24 (%11.4) had heart failure, 83 (%39.3) had coronary artery disease and 10 (%4.7) had arrhythmia. Mean range for the 6-minute walk test was 374.62 (61.75) meters before and 390.80 (62.87) meters after CR (P<0.001). Mean values of the maximum watts in cycle ergometer effort test were 50 watts before and 75 watts after CR (P<0.001). Before and after CR, NLR and TLR were 1.6, 1.4 and 107.59 (35.22), 101.46 (32.78), respectively (P<0.001). Sedimentation and CRP levels were 22.38 (11.55) mm/hour, 1.0 mg/dl before and 18.98 (10.06) mm/hour, 0.5 md/dl after rehabilitation, respectively (P<0.001).

Conclusion: CR can decrease the inflammatory markers TLR and NLR which are directly related to mortality in cardiac patients, while increasing the patients’ functional capacity.


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Research Article

How to Cite

Bilir Kaya B, Özbilgin N. Effect of cardiac rehabilitation on mortality related inflammatory markers. J Surg Med [Internet]. 2019 Aug. 1 [cited 2022 Oct. 4];3(8):588-92. Available from: https://jsurgmed.com/article/view/606487