The relationship of serum galectin-3 levels with obesity and insulin resistance

Özgür Altun; Okan Dikker; Murat Akarsu; Yücel Arman; Şengül Aydın Yoldemir; Orkide Kutlu; Perihan Özkan Gümüşkaya; Tufan Tükek

doi:10.28982/josam.602984

Authors

Özgür Altun https://orcid.org/0000-0003-1810-7490
Okan Dikker https://orcid.org/0000-0002-9153-6139
Murat Akarsu https://orcid.org/0000-0002-2675-4252
Yücel Arman https://orcid.org/0000-0002-9584-6644
Şengül Aydın Yoldemir https://orcid.org/0000-0003-4236-1181
Orkide Kutlu https://orcid.org/0000-0002-4402-2231
Perihan Özkan Gümüşkaya https://orcid.org/0000-0002-0838-9220
Tufan Tükek https://orcid.org/0000-0002-4237-1163

DOI:

https://doi.org/10.28982/josam.602984

Keywords:

Galectin-3, Obesity, Insulin Resistance, Diabetes Mellitus, Metabolic disease

Abstract

Aim: Galectin-3 affects inflammation, cell adhesion, proliferation, differentiation and angiogenesis. Upon examining the pathogenesis of obesity and functions of galectin-3, we thought that galectin-3 may play a significant role in obese patients. This study aims to evaluate the relationship between obesity, insulin resistance and galectin-3 levels.

Methods: Eighty five patients aged between 18-50 years were included in this cross-sectional study. BMI>30 were considered obese, those between 25-30 and 18-25 were considered overweight and normal weight, respectively. Patients with HOMA-IR>2.5 were considered insulin-resistant, and those with <2.5 were evaluated as insulin non-resistant.Galectin-3 levels were measured by Enzyme-linked immunosorbent assay.

Results: Serum galectin-3 levels were significantly higher in obese patients, but not statistically significantly different between those with and without insulin resistance. Galectin-3 levels were also significantly correlated with BMI and total cholesterol levels, but not correlated with HOMA-IR.

Conclusion: In obesity, serum galectin-3 levels may increase to compensate for the inflammation. Our results make it difficult to establish a relationship between insulin resistance and galectin-3.

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