The relationship of serum galectin-3 levels with obesity and insulin resistance
Keywords:Galectin-3, Obesity, Insulin Resistance, Diabetes Mellitus, Metabolic disease
Aim: Galectin-3 affects inflammation, cell adhesion, proliferation, differentiation and angiogenesis. Upon examining the pathogenesis of obesity and functions of galectin-3, we thought that galectin-3 may play a significant role in obese patients. This study aims to evaluate the relationship between obesity, insulin resistance and galectin-3 levels.
Methods: Eighty five patients aged between 18-50 years were included in this cross-sectional study. BMI>30 were considered obese, those between 25-30 and 18-25 were considered overweight and normal weight, respectively. Patients with HOMA-IR>2.5 were considered insulin-resistant, and those with <2.5 were evaluated as insulin non-resistant.Galectin-3 levels were measured by Enzyme-linked immunosorbent assay.
Results: Serum galectin-3 levels were significantly higher in obese patients, but not statistically significantly different between those with and without insulin resistance. Galectin-3 levels were also significantly correlated with BMI and total cholesterol levels, but not correlated with HOMA-IR.
Conclusion: In obesity, serum galectin-3 levels may increase to compensate for the inflammation. Our results make it difficult to establish a relationship between insulin resistance and galectin-3.
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Copyright (c) 2019 Özgür Altun, Okan Dikker, Murat Akarsu, Yücel Arman, Şengül Aydın Yoldemir, Orkide Kutlu, Perihan Özkan Gümüşkaya, Tufan Tükek
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