Mean platelet volume and platelet distribution width levels in discoid lupus erythematosus patients: A case-control study

Zeynep Gizem Kaya İslamoğlu; Abdullah Demirbaş

doi:10.28982/josam.599953

Authors

Zeynep Gizem Kaya İslamoğlu https://orcid.org/0000-0002-8141-3186
Abdullah Demirbaş https://orcid.org/0000-0002-3419-9084

DOI:

https://doi.org/10.28982/josam.599953

Keywords:

Platelets, Mean platelet volume, Platelet distribution width, Discoid lupus erythematosus, Inflammation

Abstract

Aim: Platelets (PLT) play an important role in inflammatory reactions and immune responses. This study aims to evaluate PLT and PLT parameters in patients with discoid lupus erythematosus (DLE), which is characterized by inflammation.

Methods: In this case-control study, a total of 125 participants, consisting of 60 DLE patients and 65 healthy controls, were selected to participate. PLT, platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT), the ratio of neutrophils to lymphocytes (NLR) and the ratio of platelets to lymphocytes (PLR) were studied retrospectively in both groups.

Results: The mean age of the patient group was 47.30 (15.14) years, and the mean age of the control group was 38.08 (13.33) years. There were no statistically significant differences between the PLT, PDW, MPV, PCT, NLR and PLR levels in DLE patients and healthy controls (P=0.365, P=0.988, P=0.160, P=0.851, P=0.898 and P=0.887, respectively).

Conclusion: To the best of our knowledge, there are no reports on both PLT, PDW, PCT, NLR, PLR and MPV in patients with DLE. We did not find a significant difference in the DLE group. PLT parameters are low-cost tests that can be used to define inflammation levels in inflammatory diseases. Further prospective studies on this subject will contribute to this work.

Downloads

Download data is not yet available.

References

Tsuchida T. Systemic Lupus Erythematosus. Brain Nerve. 2019 Apr;71(4):317-21.

Oh EH, Kim EJ, Ro YS, Ko JY. Ten-year retrospective clinicohistological study of cutaneous lupus erythematosus in Korea. J. Dermatol. 2018 Apr;45(4):436-43.

Gaüzère L, Gerber A, Renou F, Ferrandiz D, Bagny K, Osdoit S, et al. Epidemiology of systemic lupus erythematosus in Reunion Island, Indian Ocean: A case-series in adult patients from a University Hospital. Rev Med Interne. 2019 Apr;40(4):214-9.

Abadías-Granado I, Sánchez-Bernal J, Felipo-Berlanga F, Ara-Martín M. Coexistence of Tumid Lupus Erythematosus and Discoid Lupus Erythematosus. Actas Dermosifiliogr. 2019 Apr;110(3):253-5.

Asahina A, Kubo N, Umezawa Y, Honda H, Yanaba K, Nakagawa H. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and mean platelet volume in Japanese patients with psoriasis and psoriatic arthritis: Response to therapy with biologics. J Dermatol. 2017 Oct;44(10):1112-21.

Osselaer JC, Jamart J, Scheiff JM. Platelet distribution width for differential diagnosis of thrombocytosis. Clin Chem. 1997;43:1072‑6.

Tang J, Gao X, Zhi M, Zhou HM, Zhang M, Chen HW, et al. Plateletcrit: a sensitive biomarker for evaluating disease activity in Crohn's disease with low hs-CRP. J Dig Dis. 2015;16(3):118-24.

Leithead JA, Rajoriya N, Gunson BK, Ferguson JW. Neutrophil-to-lymphocyte ratio predicts mortality in patients listed for liver transplantation. Liver Int. 2015;35:502–9.

Kridin K, Shihade W, Zelber-Sagi S. Mean Platelet Volume in Pemphigus Vulgaris. Angiology. 2018 Apr;69(4):303-7.

Pancar GS, Eyupoglu O. Red Cell Distribution Width and Mean Platelet Volume in Patients With Pityriasis Rosea. J Clin Med Res. 2016 Jun;8(6):445-8.

Vayá A, Rivera L, Todolí J, Hernandez JL, Laiz B, Ricart JM. Haematological, biochemical and inflammatory parameters in inactive Behçet's disease. Its association with red blood cell distribution width. Clin Hemorheol Microcirc. 2014;56(4):319-24.

Boilard E, Blanco P, Nigrovic PA. Platelets: Active players in the pathogenesis of arthritis and SLE. Nat Rev Rheumatol. 2012;8:534‑42.

Habets KL, Huizinga TW, Toes RE. Platelets and autoimmunity. Eur J Clin Invest. 2013;43:746‑57.

Hoffmann JJ, Nabbe KC, Van den Broek NM. Effect of age and gender on reference intervals of red blood cell distribution width (RDW) and mean red cell volume (MCV). Clin Chem Lab Med. 2015;53(12):2015-9.

Kim DS, Lee J, Kim SH, Kim SM, Lee MG. Mean platelet volume is elevated in patients with psoriasis vulgaris. Yonsei Med J. 2015;56:712‑8.

Ozlu E, Karadag AS, Toprak AE, Uzuncakmak TK, Gerin F, Aksu F, et al. Evaluation of cardiovascular risk factors, haematological and biochemical parameters, and serum endocan levels in patients with lichen planus. Dermatology. 2016;232:438‑43.

Safak S, Uslu AU, Serdal K, Turker T, Soner S, Lutfi A, et al. Association between mean platelet volume levels and inflammation in SLE patients presented with arthritis. Afr Health Sci. 2014;14:919‑24.

Chen SY, Du J, Lu XN, Xu JH. Platelet distribution width as novel indicator of disease activity in systemic lupus erythematosus. J Res Med Sci. 2018 May 30;23:48.

Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47‑58.

Ataseven A, Bilgin AU, Kurtipek GS. The importance of neutrophil lymphocyte ratio in patients with psoriasis. Mater Sociomed. 2014;26:231–3.

Huang W, Huang J, Liu Q, Lin F, He Z, Zeng Z, et al. Neutrophil-lymphocyte ratio is a reliable predictive marker for early-stage diabetic nephropathy. Clin Endocrinol. 2014;82:229–33.

Fu H, Qin B, Hu Z, Ma N, Yang M, Wei T, et al. Neutrophil- and platelet-to-lymphocyte ratios are correlated with disease activity in rheumatoid arthritis. Clin Lab. 2015;61:269–73.