The effect of dexpanthenol on the formation of epidural fibrosis in an experimental laminectomy model in rats

Zahir Kızılay; Nesibe Kahraman Çetin; Soner Yaycıoğlu; Murat Özcan Yay; Hakan Öztürk; Çiğdem Yenisey

doi:10.28982/josam.597612

Authors

Zahir Kızılay https://orcid.org/0000-0002-2021-0406
Nesibe Kahraman Çetin https://orcid.org/0000-0002-4549-1670
Soner Yaycıoğlu https://orcid.org/0000-0001-9230-1107
Murat Özcan Yay https://orcid.org/0000-0001-8990-7642
Hakan Öztürk https://orcid.org/0000-0001-8112-4934
Çiğdem Yenisey https://orcid.org/0000-0001-7693-641X

DOI:

https://doi.org/10.28982/josam.597612

Keywords:

Laminectomy, Epidural fibrosis, Fibroblast, Dexpanthenol, Rat

Abstract

Aim: Epidural fibrosis, which develops after spinal surgery, is one of the factors which reduce the chances of successful surgery in the medium and long term by tightly surrounding the dura and spinal roots. In this experimental study, the aim was to compare the effects of local and systemic administration of dexpanthenol on epidural fibrosis formation in rats.

Methods: Twenty-eight rats were randomly divided into 4 equal groups (control, Spongostan, local dexpanthenol and systemic dexpanthenol) and laminectomy was performed at the T11 level. Local dexpanthenol (500mg/kg) was administered with Spongostan, and systemic dexpanthenol (500 mg/kg) was administered once a day for three weeks. Epidural fibrosis, arachnoidal involvement, fibroblast cell count, vascular endothelial growth factor, and hydroxyproline levels were evaluated.

Results: The grade of epidural fibrosis, fibroblast cell counts, and hydroxyproline levels were significantly lower in the systemic dexpanthenol groups (P=0.025).

Conclusion: Dexpanthenol may be used as potential agent for reducing epidural fibrosis. However, it should be administered more than once for it to take effect.

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