Is there any relationship between propofol induction dose and duration of seizure for repetitive electroconvulsive therapies?

Çiğdem Yıldırım Güçlü; Ahmet Onat Bermede; Başak Ceyda Meço; Zekeriyya Alanoğlu; Neslihan Alkış

doi:10.28982/josam.595773

Authors

Çiğdem Yıldırım Güçlü https://orcid.org/0000-0002-8416-3418
Ahmet Onat Bermede https://orcid.org/0000-0002-8598-6264
Başak Ceyda Meço https://orcid.org/0000-0003-2951-9634
Zekeriyya Alanoğlu https://orcid.org/0000-0003-4967-5829
Neslihan Alkış https://orcid.org/0000-0003-0469-2318

DOI:

https://doi.org/10.28982/josam.595773

Keywords:

Electroconvulsive therapy, Propofol, Seizure

Abstract

Aim: Anesthetic agents have been used during electroconvulsive therapy for years, but selecting the agent remains a challenge. Anesthetics may play a negative role on seizure duration, which directly affects the success of the treatment. This study is designed to see the relationship of repetitive sessions, anesthetic dose, and seizure duration.

Methods: A total of 73 ECT treatments for 11 patients were evaluated for this prospective-cohort study. After premedication, propofol was administered slowly until the patient lost eyelash reflex. The duration of the seizure, propofol dose administered, and the time between the end of the procedure and full recovery (as decided by Aldrete score) were recorded.

Results: The mean seizure time was 25.5 (10.2) seconds. There was a statistically significant correlation between seizure duration, the number of sessions and propofol dose, and no correlation between the time to reach an Aldrete score of 10 and both the number of sessions and propofol dosing.

Conclusion: An increased propofol dosage may be needed during ECT as the number of session increases, but this increase does not affect recovery time.

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