Increased signal intensity in the unenhanced T1-weighted magnetic resonance in the brain after repeated administrations of a macrocyclic-ionic gadolinium-based contrast agent



Gadoterate meglumine, Brain, Magnetic resonance imaging, Signal intensity


Aim: Gadoterate meglumine is a macrocyclic-ionic gadolinium-based contrast agent (GBCA) which is using in the magnetic resonance imaging (MRI). This study aims to determine the relationship between the signal intensity (SI) increase in the dentate nucleus (DN), pons (P), globus pallidus (GP), thalamus (T) and use gadoterate meglumine by repeated brain MRI in lung cancer patients.

Methods: The study was designed as a retrospective cohort study. The mean SIs of the DN, P, GP, and T and the cerebrospinal fluid (CSF) were measured in the unenhanced T1-weighted (T1w) images of the first and last MRIs of patients who underwent at least three brain MRI examinations with gadoterate meglumine. DN, P, GP, T SIs were divided by values obtained from CSF to standardize the SI measurements. The DN, P, GP, T SIs and DN/CSF, P/CSF, GP/CSF, T/CSF ratios were compared the first and the last MRI examinations.

Results: Our study revealed significant increases in DN, P, GP, and T SIs (P<0.001, P<0.001, P<0.001 and P=0.024,respectively). DN/CSF, P/CSF, GP/CSF, and T/CSF ratios were also significantly increased (P<0.001, P<0.001, P<0.001 and P=0.022, respectively). The number of examinations had a moderately strong positive correlation with in the DN/CSF ratio and a strong positive correlation with in P/CSF ratio (P<0.001 and P<0.001, respectively). There was a weak positive correlation between MRI intervals and in P/CSF ratio (P=0.037).

Conclusion: Our study suggested an increase in the first and the last MRI in DN, P, GP and T SIs related to the number and intervals of repeated examinations of a brain MRI with gadoterate meglumine among patients with lung cancer.


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How to Cite

Kavak RP, Özdemir M. Increased signal intensity in the unenhanced T1-weighted magnetic resonance in the brain after repeated administrations of a macrocyclic-ionic gadolinium-based contrast agent. J Surg Med [Internet]. 2019 Jul. 29 [cited 2024 Apr. 18];3(7):507-11. Available from: