Breast myofibroblastoma: Report of two cases with literature review



Myofibroblastoma, Breast, Spindle cell


Myofibroblastoma (MFB) is a rare mesenchymal benign tumor that arises from the stromal structures of the breast tissue. It occurs in the elderly without sex predilection. Its clinical and radiological presentations are aspecific, thus MFB may be confounded with other malignant and benign breast lesions. However, the main histological characteristic of MFB is the presence of spindle cells in a collagenous background. In immunohistochemistry, MFB is positive for vimentin and CD34 with a noticeable low mitotic activity. Surgical excision remains the treatment cornerstone, with excellent outcomes. We retrospectively reviewed the records of all the patients who underwent surgery of breast from 01 January 2012 to 31 December 2018. We found two cases of breast myofibroblastoma. The first was a young woman aged 17 years, and the second was a male aged 87 years. The main symptom was a palpable breast lump in both patients. The radiological work up concluded to a benign lump in the young woman, and a suspicious breast lump in the man, to whom we performed a core biopsy. Histology staining showed the features of MFB. The woman underwent a lumpectomy, and the man underwent a mastectomy. Final histological staining showed spindle cells with a collagen matrix. The cells were positive for CD34, vimentin, and actin. Those features were compatible with the diagnosis of breast MFB. The aim of this report was to describe the clinical, radiological and histological features of breast MFB.


Download data is not yet available.


Wagortz ES, Weiss SW, Norris HJ. Myofibroblastoma of the breast: sixteen cases of a distinctive benign mesenchymal tumor. Am J Surg Pathol. 1987;11:493–502.

Magro G. Mammary myofibroblastoma: a tumor with a wide morphologic spectrum. Arch Pathol Lab Med. 2008;132(11):1813–20.

Howitt BE, Fletcher CD. Mammary-type myobroblastoma: clinicopathologic characterization in a series of 143 cases. Am J Surg Pathol. 2016;40:361–7.

Magro G, Caltabiano R, Kacerovská D, Vecchio GM, Kazakov D, Michal M. Vulvovaginal myofibroblastoma: expanding the morphological and immunohistochemical spectrum. A clinicopathologic study of 10 cases. Hum Pathol. 2012;43(2):243–53.

Zhang Y, Jorda M, Goldblum JR. Perianal mammary-type myofibroblastoma. Ann Diagn Pathol. 2010;14:358–60.

Mukonoweshuro P, McCormick F, Rachapalli V, Natale S, Smith ME. Paratesticular mammary-type myofibroblastoma. Histopathology. 2007;50:396–7.

Scotti C, Camnasio F, Rizzo N, Fontana F, De Cobelli F, Peretti GM, et al. Mammary-type myofibroblastoma of popliteal fossa. Skeletal Radiol. 2008;37(6):549–53.

Comer JD, Cui X, Eisen CS, Abbey G, Arleo EK. Myofibroblastoma of the male breast: A rare entity with radiologic-pathologic correlation. Clinical imaging. 2017;42:109–12.

Reis-Filho JS, Faoro LN, Gasparetto EL, Totsugui JT, Schmitt FC. Mammary epithelioid myofibroblastoma arising in bilateral gynecomastia: Case report with immunohistochemical profile. Int J Surgical Pathol. 2001;9(4):331–4.

Sanmugasiva VV, Ramli MT, fadzli F, Kaur S, Abd Rahman N, Rahmat K. Myofibroblastoma of the breast. Malaysian J Pathol. 2018;40(3):349–53.

Khatib Y, Pandey V, Khade AL, Pandey R. Myofibroblastoma of the Breast: A Rare Cause of Breast Lump in a Postmenopausal Woman. J Midlife Health. 2018;9(1):47–9.

Yoo EY, Shin JH, Ko EY, Han BK, Oh YL. Myofibroblastoma of the female breast: Mammographic, sonographic, and magnetic resonance imaging findings. J Ultrasound Med. 2010;29:1833–6.

McMenamin ME, Fletcher CD. Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma. Am J Surg Pathol. 2001;25:1022–9.






Case Report

How to Cite

Bouhani M, Adouni O, Marghli İkram, Chemlali M, Chargui R, Rahal K. Breast myofibroblastoma: Report of two cases with literature review. J Surg Med [Internet]. 2020 May 1 [cited 2024 Apr. 19];4(5):429-31. Available from: