Is there any association between calcium values and otosclerosis?
Keywords:Otosclerosis, Conductive hearing loss, Calcium, Stapedectomy
Aim: Otosclerosis; is an idiopathic disease caused by the occupation of the otic capsule and the stapes base with the spongioform bone. It is the most common type of conductive hearing loss after otitis media in otorhinolaryngology. There are no studies in the literature showing the relationship between blood calcium levels and hearing loss. The aim of this study is to investigate the blood calcium levels and hearing loss of patients with otosclerosis diagnosed retrospectively.
Methods: The study was performed case-control study. Patients were divided into two groups: patient and control. The patient group consisted of 40 patients who were operated for otosclerosis in the otolaryngology clinic between 2013 and 2017. Calcium values in the blood biochemistry of these patients and preoperative hearing tests were recorded retrospectively. The control group admitted for any reason, the otolaryngology clinic and consisted of 40 patients with non-ear disease. Calcium values in blood biochemistry and hearing tests performed in outpatient clinic were recorded retrospectively. The hearing of the patients in both groups was recorded by taking the average of the right and left ear.
Results: The mean age of the control group was 28 (2.4) (18-60) years. The mean age for the patient group was 32 (2.6) (19-68). No significant difference was observed between the two groups in terms of age (P=0.061). The control group was 10.8 (1.2) dB on the right and the left ear. The mean calcium blood levels in the control group were 9.8 (0.4) mg/dL. The mean right and left ear audiometry of the patient group was 38 (0.6) dB. The mean blood calcium level of the patient group was 11.7 (0.9) dB. There was a significant difference between the control group and the patient group in the audiometry test (P=0.024). There was no significant difference between the patient group and the control group in terms of blood calcium (P=0.078).
Conclusion: There was a significant deterioration in hearing in patients with otosclerosis. However, there was no significant increase in blood calcium levels. Therefore, there was no significant relationship between blood calcium level and hearing in otosclerosis.
Tuncer Ü, Tarkan Ö. Otosklerozun fizyopatolojisi. Türkiye Klinikleri J E.N.T- Special Topics. 2009;2(3):1-4.
Politzer A. Ueber primare Erkrankung der knochernen Labyrinth kapsel. Z Ohrenheilkd. 1893;25:309.
Çolpan B, Öztürk K, Elsürer Ç, Kibar E, Erdur Ö. Otosklerozlu olguların analizi. Kulak Burun Boğaz Uygulamaları Dergisi. 2016;4(3):105-10
Bilgen C. Otoskleroz Epidemiyolojisi. Türkiye Klinikleri J.E.N.T- Special Topics. 2009;2(3):5-8.
Michaels L, Soucek S. Origin and growth of otosclerosis. Acta Otolaryngol. 2011;131(5):460-8.
Odabaşı AO. Otosklerozda Radyolojik Tanı. Turkiye Klinikleri Ear Nose and Throat-Special Topics. 2009;2(3):20-3.
Uppal S, Bajaj Y, Coatesworth AP. The medical management ofotosclerosis. Int J Clin Pract. 2010;64(2):256-65.
Penido N, Vicente A. Medical Management of Otosclerosis. Otolaryngol Clin North Am. 2018;51(2):441-52.
Nazarian R, McElveen JT, Eshraghi AA. History of otosclerosis and stapes surgery. Otolaryngol Clin North Am. 2018;51(2):275-90.
Güneri EA, Ceryan K, Ada E, Güneri A. High-resolution computed tomographic evaluation of the cochlear capsule in otosclerosis: relationship between densitometry and sensorineural hearing loss. Ann Otol Rhinol Laryngol. 1996;105(8):659-64.
Rüedi L, Spoendlin HXL. Pathogenesis of Sensorineural Deafness in Otosclerosis. Ann Otol Rhinol Laryngol. 1966;75(2):525–52.
Soifer N, Altmann F, Endahl GL, Holdsworth C. Biochemical Studies of Otosclerosis: II. Total Serum Alkaline Phosphatase. Eur Arch Otorhinolaryngol. 1965;82:108-9.
Brookes GB. Vitamin D deficiency and otosclerosis. Otolaryngol Head Neck Surg. 1985;93(3):313-21.
Baysal E. Oxidative stress in otosclerosis. Redox Rep. 2017;22(5):235-9.
Rudic M. Keog of otosclerosis: review of current research. Hear Res. 2015;330:51-6.
Aurbach GDS, Marx J, Spiegel AM. Parathyroid hormone, calcitonin and the calciferols. William's Textbook of Endocrinology. PA Saunders, Philadelphia, pp. 1992; 1397-453.
Soifer N, Altmann F, Endahl GL, Holdsworth CE, Weaver K. Biochemical studies of otosclerosis: Protein and enzymes in stapedes and cortical bone. Acta Otolaryngol. 1969;68(1-6):78-84.
Wiatr A, Składzień, J, Świeży K, Wiatr MA. Biochemical Analysis of the Stapes. Med Sci Monit. 2019;25:2679-86.
- 1110 1744
How to Cite
Copyright (c) 2019 Erkan Yıldız, Orhan Kemal Kahveci, Şahin Ulu, Halit Buğra Koca
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.