Investigation of inflammation with neutrophil/lymphocyte ratio in restless legs syndrome



Inflammation, Restless legs syndrome, Neutrophil/lymphocyte ratio


Aim: Restless Legs Syndrome (RLS) is a chronic, progressive, sensorimotor disorder characterized by the urge to move legs and abnormal sensations in the limbs. The pathophysiology of RLS is not clear. In recent years, many studies have used different serum biomarkers to discuss pathophysiology or to follow up the diagnosis and treatment. There are not enough studies that entirely investigating the relationship between RLS and serum neutrophil/lymphocytes (N/L). Therefore, in this study it was aimed to examine the relationship between idiopathic RLS and serum N/L.

Methods: A case control study was planned. After sample size analysis, 93 patients with diagnosed RLS (study group) and age- and gender matching 50 healthy volunteers (control group) were included in the study. N/L ratio were compared between two groups.

Results: The median of N/L ratio was 2.58 in the RLS group and 2.72 in the control group. There was no statistically significant difference between the groups (p=0.891). The mean duration of disease was 3.2±1.37 years in patients’ group. Sleep disorders were found in 81.7% (n=76) of the patients, and similar complaints were observed on the upper extremities in 34.4% (n=32) of the patients. Severity scale of disease was determined according to the International Restless Legs Syndrome Study Group (IRLSSG). It was observed to be low severity of the symptom in 6.3%, middle severity of the symptom in 15.2%, severe severity of the symptom in 64.8%, high severity of the symptom in 13.7% of the patients. There was no correlation neither between duration of disease and N/L ratio (r:-0.117, p=0.281) nor between severity of the symptoms and N/L (r:0.68, p=0.413). 

Conclusion: In this study, it was investigated the role of inflammation in the pathophysiology of RLS was evaluated with N/L ratio and it was not observed statistically significance on behalf of patients group.


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Sonkaya AR, Ceylan M. Investigation of inflammation with neutrophil/lymphocyte ratio in restless legs syndrome. J Surg Med [Internet]. 2019 Apr. 28 [cited 2024 May 18];3(4):288-91. Available from: