Effect of adrenocorticotropin hormone and cortisol on epithelial sodium channels according to delivery route

Authors

Keywords:

Adrenocorticotropin hormone, Cortisol, Epithelial sodium channels, Delivery route

Abstract

Aim: Immaturity of epithelial sodium channels (ENaC), which are affected by adrenocorticotropin hormone (ACTH) and cortisol, is believed to be the major underlying cause of transient tachypnea of the newborn. The aim of this study is to investigate the differences in ACTH and cortisol levels and the expression of lung ENaC α subunit of the babies in relation to mode of delivery.

Methods: The study was planned as prospective cohort study. Eighteen women who underwent elective caesarean section (C/S) and fifteen women who admitted to hospital for normal spontaneous delivery (NSD) and their term 33 newborn infants were included in the study. Blood samples for ACTH and cortisol levels were collected from the mothers prior to birth and the newborn infants 1 hour after birth. Nasal mucosa species of the infants were performed to assess ENaC α subunit levels. 

Results: The ACTH and cortisol levels of mothers of C/S group were lower than the ACTH and cortisol levels of mothers of NSD group (p<0.001). Although the ACTH levels of infants delivered by C/S were significantly higher than the ACTH levels of infants delivered by NSD (p=0.001), no significant difference was identified between them with regards to the levels of cortisol (p=0.078) and ENaC α subunits (p:0.671). 

Conclusion: Our results suggest that hormonal mechanisms in newborn infants function independently from their mothers. In term babies mode of delivery is not the major factor affecting the expression of ENaC α subunit.

Downloads

Download data is not yet available.

References

Shehata MF. Regulation of the epithelial sodium channel [ENaC] in kidneys of salt-sensitive Dahl rats: Insights on alternative splicing. International Archives of Medicine. 2009;2:28. Doi:10.1186/1755-7682-2-28

Helve O, Pitkanen OM, Janer C, Andersson S. Pulmonary Fluid Balance in the Human Newborn Infant. Neonatology. 2009;95:347-52. Doi: 10.1159/000209300

Landmann E, Schmidtpott M, Tutdibi E, Gortner L. Is Transient Tachypnoea of the Newborn Associated With Polymorphisms in the Epithelial Sodium Channel Encoding Gene? Investigation of the Second Transmembrane Spanning Domain of the Alpha Subunit. Acta Paediatrica. 2005;94:317-23.

Sheheta MF. Characterization of the epithelial sodium channel alpha subunit coding and non-coding transcripts and their corresponding mRNA expression levels in Dahl R versus S rat kidney cortex on normal and high salt diet. Int Arch Med. 2009;2:1-9. Doi: 10.1186/1755-7682-2-5

Kamel RM. The onset of human parturition. Arch Gynecol Obstet. 2010;281:975-82. Doi: 10.1007/s00404-010-1365-9

Tutdibi E, Gries K, Bücheler M, Misselwitz B, Schlosser RL, Gortner L. Impact of labor on outcomes in transient tachypnea of the newborn: population-based study. Pediatrics. 2010;125:577-83. Doi: 10.1542/peds.2009-0314

Stutchfield P, Whitaker R, Russell I. Antenatal Steroids for Term Elective Caesarean Section (ASTECS) Research Team. Antenatal Betamethasone and incidence of neonatal respiratory distress after elective cesarean section: pragmatic randomised trial. BMJ. 2005;331:662-75. Doi:10.1136/bmj.38547.416493-06

Tita ATN, Landon MB, Spong CY, Lai Y, Leveno KJ, Varner MW. Timing of elective repeat cesarean delivery at term and neonatal outcomes. N Eng J Med. 2009;360:111-20. Doi: 10.1056/NEJMoa0803267

Ramachandrappa A, Jain L. Elective cesarean section: Its impact on neonatal respiratory outcomes. Clin Perinatol. 2008;35:373-93. Doi: 10.1016/j.clp.2008.03.006

Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Plavka R, et all. Europen Consensus guidelines on the manegement of Neonatal respiratory distress syndrome in preterm infants-2010 update. Neonatology. 2010;97:402-17. Doi: 10.1159/000297773

American College of Gynecology Practice bulletin: Induction of labor. Obstet Gynecol. 2009;114:386-97. Doi: 10.1097/AOG.obo13e3181b48ef5.

Vogl SE, Worda C, Egarter C, Bieglmayer C, Szekeres T, Huber J, Husslein P. Mode of delivery is aassociated witth maternal and fetal endocrine stress response. BJOG. 2006;113:441-5. Doi: 10.1111/j.1471-0528.2006.00365X

Ochedalski T, Lachowicz A. Maternal and fetal hypothalamo-pituitary- adrenal axis: different response depends upon the mode of parturition. Neuroendocrinol Lett. 2004;25:278-82.

Zenciroğlu A, Arsan S, Koç E, Ertoğan F. Yenidoğanlarda doğum şekliyle ACTH, kortizol ve glukoz düzeyleri arasındaki ilişki. T Klin Pediatri. 1997;6:60-3.

Bacigalupo G, Lagner K, Schmidt S, Saling E. Plasma immunoreactive beta-endorphin, ACTH and cortisol concentrations in mothers and their neonates immediately after delivery their relationship to the duration of labor. J Perinat Med. 1987;15:45-50.

Kandemir H, Belet N, Aydın M, Küçüködük Ş. Elektif sezaryen ve normal vajinal yolla doğan bebeklerde ACTH, kortizol, büyüme hormonu, prolaktin ve kan glikoz düzeylerinin karşılaştırılması. O.M.Ü Tıp Dergisi. 2001;18:30-5.

Mears K, Mcauliffe F, Grimes H, Morrison JJ. Fetal cortisol in relation to labor, intrapartum events and mode of delivery. J Obstet Gynecol. 2004;24:129-32. Doi: 10.1080/01443610410001645389

Baines DL, Folkesson HG, Norlin A, Bingle CD, Yuan HT, Olver RE. The influence of mode of delivery, hormonal status and postnatal O2 environment on epithelial sodium channel (ENaC) expression in perinatal guinea-pig lung. J Physiol. 2000;522:147-57. Doi: 10.1111/j.1469-7793.2000.t01-2-00147.xm

Helve O, Janer C, Pitkanen O, Andersson S. Expression of the epithelial sodium channel in airway epithelium of newborn infants depends on gestational age. Pediatrics. 2007;120:1311-6. Doi: 10.1542/peds.2007-0100

Janer C, Pitkanen OM, Helve O, Andersson S. Airway expression of the epithelial sodium channel α-subunit correlates with cortisol in term newborn. Pediatrics. 2011;128:414-21. Doi: 10.1542/peds.2011-0167

Downloads

Published

2019-02-25

Issue

Section

Research Article

How to Cite

1.
Tezel G, Öztekin O, Kalay S, Akdağ M, Turhan M, Erin N, Akçakuş M, Oygur N. Effect of adrenocorticotropin hormone and cortisol on epithelial sodium channels according to delivery route. J Surg Med [Internet]. 2019 Feb. 25 [cited 2022 Dec. 7];3(2):163-8. Available from: https://jsurgmed.com/article/view/518414