Comparing the effects of silver sulfadiazine and cerium nitrate silver sulfadiazine on burn-wound healing and survival rate of rat animal model

Latifi Nur-Ahmad; Fatemi-Dokhtcharuk Mohammad-Javad; Salahi-Kajur Ali-Asghar; Hedayatpour Azim

doi:10.28982/josam.515121

Authors

Latifi Nur-Ahmad https://orcid.org/0000-0003-2046-637X
Fatemi-Dokhtcharuk Mohammad-Javad https://orcid.org/0000-0002-4836-5282
Salahi-Kajur Ali-Asghar https://orcid.org/0000-0002-3434-3656
Hedayatpour Azim https://orcid.org/0000-0002-1036-0697

DOI:

https://doi.org/10.28982/josam.515121

Keywords:

Skin-burn, Cerium nitrate silver sulfadiazine, Wound-healing, Mortality, Animal model

Abstract

Aim: Current studies about burn therapy are focusing on survival rate of patients with severe burned. So, here we aim to assess the effects of cerium nitrate silver sulfadiazine (CN+SSD) and compare with SSD ointment on mortality and burn healing in rat animal model.

Methods: Twenty rats were used in this study. After inducing burn wounds on back skin of animals, they were classified into two groups randomly. In one group, SSD was administrated topically immediately after inducing burn wound and in the other the combination of CN+SSD was applied. The treatments in both groups were continued as administration of the ointments two times per day for 28 days. Animal’s weight and wound sizes were measured 7, 14, 21 and 28 days after burn induction in all animals. The mortality of rats as well as their wound histopathology was also evaluated.

Results: On day 28, wound’s average size was decreased to 25 and 27% of initial area in SSD and CN +SSD groups, respectively. In CN+SSD group, the wound size was not smaller than SSD group significantly. Histological comparison has demonstrated no significant differences between CN+SSD group and SSD treated.

Conclusion: The results of our study did not show any differences between CN+SSD and SSD topical treatments in terms of wound healing and mortality rate in rat animal model significantly.

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