Synchronous association of gastrointestinal stromal tumors of the jejunum and sigmoidal adenocarcinoma: A case report

Houssam Belghali; Anas Belhaj; Karim Ibn Majdoub; İmane Taughrai; Khalid Mazaz

doi:10.28982/josam.453908

Authors

Houssam Belghali https://orcid.org/0000-0002-6734-2094
Anas Belhaj https://orcid.org/0000-0002-1118-1594
Karim Ibn Majdoub https://orcid.org/0000-0002-0421-7296
İmane Taughrai https://orcid.org/0000-0003-0401-3012
Khalid Mazaz https://orcid.org/0000-0001-7779-7802

DOI:

https://doi.org/10.28982/josam.453908

Keywords:

Synchronous tumors, Gastrointestinal stromal tumor, Adenocarcinoma, Digestive tract

Abstract

The association of a gastrointestinal stromal tumor (GIST) with an epithelial tumor of the digestive tract is very rare and frequently discovered by chance during the surgical treatment of digestive carcinoma. These tumors developed from the mesenchyme are known to have a good prognosis given their low malignancy potential. The possibility of a genetic mutation or an oncogenic agent capable of inducing tumors of different histotypes seems less plausible but it is not to be discarded. We report the case of a 74-year-old patient, operated for a sigmoid adenocarcinoma, with incidental discovery of a small bowel tumor whose histology confirmed the diagnosis of a GIST.

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References

M’sakni I, Rammeh S, Chelbi E, et al. Adénocarcinome et tumeur stromale digestifs : association fortuite ou mécanisme oncogène commun : propos de deux observations. Ann Chir. 2006;131:464–7.

Miettinen M, Lasota J. Gastrointestinal stromal tumors pathology and prognosis at different sites. Semin Diagn Pathol. 2006;23:70–83.

Maiorana A, Fante R, Maria Cesinaro A, Adriana Fano R. Synchronous occurrence of epithelial and stromal tumors in the stomach: a report of a 6 cases. Arch Pathol Lab Med. 2000;124:682–6.

Kaffes A, Hughes L, Hollinshead J, Katelaris P. Synchronous primary adenocarcinoma, mucosa-associated lymphoid tis- sue lymphoma and a stromal tumor in a Helicobacter pylori infected stomach. J Gastroenterol Hepatol. 2002;17:1033–6.

Agaimy A, Wunsch PH, Sobin LH, et al. Occurrence of other malignancies in patients with gastrointestinal stromal tumors. Semin Diagn Pathol. 2006;23:120–9.

Wronski M, Ziarkiewicz-Wroblewska B, et al. Synchronous occurrence of gastrointestinal stromal tumors and other primary gastrointestinal neoplasms. World J Gastroenterol. 2006;12:5360–62.

Pandurengan RK, Dumont AG, Araujo DM, et al. Survival of patients with multiple primary malignancies: a study of 783 patients with gastrointestinal stromal tumor. Ann Oncol. 2010;21:2107–11.

Melis M, Choi EA, Anders R, et al. Synchronous colorectal adenocarcinoma and gastrointestinal stromal tumor (GIST). Int J Colorectal Dis. 2007;22:109–14.

Chacon M, Roca E, Barugel M, et al. Report of solid cancer in patients with gastrointestinal stromal tumors. J Clin Oncol. 2004;22(14S):9065.

Cohen A, Geller SA, Horowitz I, et al. Experimental models for gastric leiomyosarcoma. The effects of N-methyl- N-nitrosoguanidine in combination with stress, aspirin or sodium taurocholate. Cancer. 1984;53:1088–92.