Intensity-modulated radiation therapy reduces late salivary toxicity and mandibular osteoradionecrosis in the treatment of oral cavity cancer: Retrospective study
Keywords:Intensive modulated radiotherapy, Oral cavity cancer, Xerostomia, Mandibular osteoradionecrosis
Aim: It is increasingly being recognized that oral cavity cancer incidences are rising globally. Irradiation using 3D conformal radiotherapy results in high incidence of late radiation side-effects. Xerostomia and manibudlar osteoradionecrosis result in most significant effects on patients quality of life. Intensive modulated radiotherapy (IMRT) is an advanced approach to 3D treatment planning and conformal radiotherapy. It optimizes the delivery of irradiation to irregularly-shaped volumes and has the ability to spare normal tissue while delivering adequate doses to the tumor volumes. In present retrospective analysis, we aimed to analyze the clinical and dosimetric characteristics with the dose constraints in patients followed for oral cavity cancer and treated by IMRT.
Methods: 19 patients followed for non-metastatic oral cavity cancer who were treated with IMRT, were retrospectively analyzed at the radiotherapy department Hassan II University hospital, Fes, Morocco between January 2016 and December 2016.
Results: The mean age was 58.5 years. The predominant histological type was epidermoid carcinoma. RCC was received in 79% of cases versus 15.8% of exclusive radiotherapy. 68.4% of cases received 70Gy for HR PTV, the mean dose delivered to the homolateral and controlateral parotid glands was 36Gy and 22Gy respectively, the average dose delivered to the mandible was 51.9Gy.
Conclusion: IMRT of oral cavity tumors offers reduces the risks of xerostomia and ORN through parotid and mandibular sparing, without compromising on target volume coverage.
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Copyright (c) 2018 Terrab Fatima Zahrae, Allouche Fadwa, El Mazghi Abderrahmane, Bouhafa Touria, Hassouni Khalid
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