The co-evaluation of endosalpingeal karyorrhexis and salpingitis after the erythropoietin effect on fallopian ischemia reperfusion injury
Keywords:Ischemia, Erythropoietin, Endosalpingeal karyorrhexis, Salpingitis, Reperfusion
Aim: This study co-evaluated the 2 quoted histologic variables after the cytokine erythropoietin (Epo) administration. The calculation was based on the results of 2 preliminary studies, each one evaluating a respective histologic variable of endosalpingeal karyorrhexis (EK) or salpingitis (S) in an induced ischemia reperfusion (IR) animal experiment.
Methods: The 2 main experimental endpoints at which the EK and S scores were evaluated, were the reperfusion 60thmin (for A & C groups) and the reperfusion 120thmin (for B & D groups). Specially, the groups A and B were processed without drugs, whereas the groups C and D after Epo administration.
Results: The first preliminary study showed that Epo hardly non significantly increased the EK scores by the grade “without lesions” 0.0181818 [-0.0679319 - +0.1042955] (p-value=0.6715). The other preliminary study found that Epo did not influence the S scores (p-value=1.0000). Both studies were co-estimated since they belong to the same experimental setting. This study co-evaluated the combined diagnostic values of both variables together.
Conclusions: Epo again hardly non significantly increased both scores for these histologic parameters at the grade of “without lesions” 0.0090909 [-0.0339659 - +0.0521478] (p-value=0.6715) since they were co-evaluated together.
Tsompos C, Panoulis C, Toutouzas K, Agrogiannis G, Patsouris E, Zografos G, Papalois A. The effect of erythropoietin on endosalpingeal karyorrhexis during ischemia reperfusion injury in rats. Acta Angiol 2014;20(3):119–23.
Tsompos C, Panoulis C, Τοutouzas K, Ζografos G, Papalois A. The Effect of Erythropoietin on Salpingitis during Ischemia Reperfusion Injury in Rats. Austin J Reprod Med Infertil. 2015;2(5):1027.
Adamyan LV, Myinbayev OA, Kulakov VI. Use of fibrin glue in obstetrics and gynecology: a review of the literature. Int J Fertil. 1991 Mar-Apr;36(2):76-7:81-8.
Castadot RG. Oral contraception in 1983 (author's transl). Contracept Fertil Sex (Paris). 1982 Nov;10(11):753-7.
Guennoun A, Krimou Y, Mamouni N, Errarhay S, Bouchikhi C, Banani A. Normal adnexal torsion and pregnancy: about a case. Pan Afr Med J. 2017 Jul 14;27:197.
Çılgın H, Şimşek M, Bal R. Can adnexal torsion be predicted by measuring plasma heat shock protein 70 level? An experimental study. Arch Gynecol Obstet. 2017 Nov;296(5):941-6.
Ayachi A, Blel Z, Khelifa N, Mkaouer L, Bouchahda R, Mourali M. Adnexal torsion during the second trimester of pregnancy: about two cases. Pan Afr Med J. 2016 Oct 25;25:113.
Sukkong K, Sananpanichkul P, Teerakidpisan P, Bhamarapravatana K, Suwannarurk K. High Rate of Gangrenous Adnexal Torsion: Dilemma of a Missing Silent Cancer. Asian Pac J Cancer Prev. 2016 Nov 1;17(11):4981-4984.
Lee MH, Meyers N, Raptis CA, Mellnick VM. Interobserver reliability for computed tomography findings of adnexal torsion. Emerg Radiol. 2017 Feb;24(1):21-24.
Damasceno RW, Avgitidou G, Belfort R Jr, Dantas PE, Holbach LM, Heindl LM. Eyelid aging: pathophysiology and clinical management. Arq Bras Oftalmol. 2015 Sep-Oct;78(5):328-31.
Spinelli C, Piscioneri J, Strambi S. Adnexal torsion in adolescents: update and review of the literature. Curr Opin Obstet Gynecol. 2015 Oct;27(5):320-5.
Tunç SY, Ağaçayak E, Yaman NS, Deveci E, Kalkanlı S, Özler A. Effects of adnexal torsion on the Fallopian tube in rats: a histologic and immunohistochemical study. Anal Quant Cytopathol Histpathol. 2014 Oct;36(5):285-9.
Türk E, Karaca İ, Ozcinar E, Celebiler A, Aybek H, Ortac R, Güven A. The effect of hypothermia on adnexal torsion/detorsion injury in a rat ovary model. J Pediatr Surg. 2015 Aug;50(8):1378-81.
Calis P, Bozdag G, Karakoc Sokmensuer L, Kender N. Does ischemia-reperfusion injury affect ovarian reserve and follicle viability in a rat model with adnexal torsion? Eur J Obstet Gynecol Reprod Biol. 2015 Feb;185:126-30.
Navve D, Hershkovitz R, Zetounie E, Klein Z, Tepper R. Medial or lateral location of the whirlpool sign in adnexal torsion: clinical importance. J Ultrasound Med. 2013 Sep;32(9):1631-4.
Sánez HA, Taboada-Pérez GC, Hernández-Arroyo L, Mateo-Madrigal M, Mateo-Madrigal V. Adnexal torsion: three cases. Ginecol Obstet Mex. 2013 May;81(5):272-8.
Hirth D, McClain SA, Singer AJ, Clark RA. Endothelial necrosis at 1 hour postburn predicts progression of tissue injury. Wound Repair Regen. 2013 Jul-Aug;21(4):563-70.
Ozler A, Turgut A, Soydinç HE, Sak ME, Evsen MS, Alabalik U, Basarali MK, Deveci E. The biochemical and histologic effects of adnexal torsion and early surgical intervention to unwind detorsion on ovarian reserve: an experimental study. Reprod Sci. 2013 Nov;20(11):1349-55.
Tsompos C, Panoulis C, Toutouzas K, Triantafyllou A, Zografos G, Papalois A. The effect of erythropoietin on chloride levels during hypoxia reoxygenation injury in rats. Signa Vitae 2017;13(2):97-101.
How to Cite
Copyright (c) 2018 Tsompos Constantinos, Panoulis Constantinos, Toutouzas Konstantinos, Triantafyllou Aggeliki, C. Zografos George, Papalois Apostolos, Kalliopi Tsarea, Maria Karamperi
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.