The co-evaluation of endosalpingeal karyorrhexis and salpingitis after the erythropoietin effect on fallopian ischemia reperfusion injury


  • Tsompos Constantinos
  • Panoulis Constantinos
  • Toutouzas Konstantinos
  • Triantafyllou Aggeliki
  • C. Zografos George
  • Papalois Apostolos
  • Kalliopi Tsarea
  • Maria Karamperi


Ischemia, Erythropoietin, Endosalpingeal karyorrhexis, Salpingitis, Reperfusion


Aim: This study co-evaluated the 2 quoted histologic variables after the cytokine erythropoietin (Epo) administration. The calculation was based on the results of 2 preliminary studies, each one evaluating a respective histologic variable of endosalpingeal karyorrhexis (EK) or salpingitis (S) in an induced ischemia reperfusion (IR) animal experiment.

Methods: The 2 main experimental endpoints at which the EK and S scores were evaluated, were the reperfusion 60thmin (for A & C groups) and the reperfusion 120thmin (for B & D groups). Specially, the groups A and B were processed without drugs, whereas the groups C and D after Epo administration.

Results: The first preliminary study showed that Epo hardly non significantly increased the EK scores by the grade “without lesions” 0.0181818 [-0.0679319 - +0.1042955] (p-value=0.6715). The other preliminary study found that Epo did not influence the S scores (p-value=1.0000). Both studies were co-estimated since they belong to the same experimental setting. This study co-evaluated the combined diagnostic values of both variables together.

Conclusions: Epo again hardly non significantly increased both scores for these histologic parameters at  the grade of “without lesions” 0.0090909 [-0.0339659 - +0.0521478] (p-value=0.6715) since they were co-evaluated together.


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How to Cite

Constantinos T, Constantinos P, Konstantinos T, Aggeliki T, George CZ, Apostolos P, Tsarea K, Karamperi M. The co-evaluation of endosalpingeal karyorrhexis and salpingitis after the erythropoietin effect on fallopian ischemia reperfusion injury. J Surg Med [Internet]. 2018 May 1 [cited 2024 Jul. 15];2(2):65-8. Available from: