Assessment of risk factors affecting thrombosis in patients with essential thrombocytosis
Keywords:Thrombosis history, Essential thrombocytosis, Janus kinase 2 mutation, Leukocyte count, Platelet count
Aim: Arterial and venous thromboembolic complications are the leading cause of morbidity and mortality in Essential thrombocytosis (ET). The mechanism of thrombosis in ET is not fully explained. In present retrospective analysis, we aimed to investigate the association between thrombosis complication and age, gender, disease duration, laboratory findings, janus kinase 2 (JAK2) V617F mutation status in patients with ET.
Methods: Medical database of ET patients whom admitted to outpatient clinics of our institution, between April 2015 and April 2017, were retrospectively analyzed. Patients were divided into two groups, with and without arterial or venous thrombosis history. According to the thrombosis story, general characteristics, laboratory findings and JAK2 V617F mutation status of the groups were compared.
Results: 37 patients with thrombosis history and 15 patients without thrombosis history were detected. The number of leukocyte, platelet and lymphocyte in ET patients with thrombosis history was statistically significantly higher than without thrombosis history patients. JAK2 V617F mutation positivity was statistically significant in ET patients with thrombosis history.
Conclusion: This study confirmed the high leukocyte count, high platelet and lymphocyte count and JAK2 V617F mutation positivity as the thrombosis risk factor in patients with ET. In addition, the characteristics of the patients who applied to our clinic were compared with the literature and the differences were revealed.
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