Assessment of risk factors affecting thrombosis in patients with essential thrombocytosis


  • Mehmet Zahid Koçak Abant Izzet Baysal University Hospital, Department of Internal Medicine
  • Mehmet Dağlı Selcuk University Medical School, Department of Hematology
  • Kemal Fidan Selcuk University Medical School, Department of Internal Medicine


Thrombosis history, Essential thrombocytosis, Janus kinase 2 mutation, Leukocyte count, Platelet count


Aim: Arterial and venous thromboembolic complications are the leading cause of morbidity and mortality in Essential thrombocytosis (ET). The mechanism of thrombosis in ET is not fully explained. In present retrospective analysis, we aimed to investigate the association between thrombosis complication and age, gender, disease duration, laboratory findings, janus kinase 2 (JAK2) V617F mutation status in patients with ET.

Methods: Medical database of ET patients whom admitted to outpatient clinics of our institution, between April 2015 and April 2017, were retrospectively analyzed. Patients were divided into two groups, with and without arterial or venous thrombosis history. According to the thrombosis story, general characteristics, laboratory findings and JAK2 V617F mutation status of the groups were compared.

Results: 37 patients with thrombosis history and 15 patients without thrombosis history were detected. The number of leukocyte, platelet and lymphocyte in ET patients with thrombosis history was statistically significantly higher than without thrombosis history patients. JAK2 V617F mutation positivity was statistically significant in ET patients with thrombosis history.

Conclusion: This study confirmed the high leukocyte count, high platelet and lymphocyte count and JAK2 V617F mutation positivity as the thrombosis risk factor in patients with ET. In addition, the characteristics of the patients who applied to our clinic were compared with the literature and the differences were revealed.


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Research Article

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Koçak MZ, Dağlı M, Fidan K. Assessment of risk factors affecting thrombosis in patients with essential thrombocytosis. J Surg Med [Internet]. 2018 May 1 [cited 2024 May 25];2(2):46-9. Available from: