Primary pancreatic lymphoma and metastatic lymphoma cases diagnosed with ultrasonography guided tru-cut needle biopsy; Two case reports: Pancreatic lymphoma, two case reports

Işıl  Bağcı; Nazlı Sena  Şeker

doi:10.28982/josam.1122921

Authors

Işıl Bağcı Department of Pathology, Osmangazi University Medicine Faculty, Eskişehir, Turkey https://orcid.org/0000-0001-5211-5430
Nazlı Sena Şeker Department of Pathology, Osmangazi University Medicine Faculty, Eskişehir, Turkey https://orcid.org/0000-0003-4588-7250

DOI:

https://doi.org/10.28982/josam.1122921

Keywords:

primary pancreatic lymphoma, pancreas, metastatic disease, diffuse large B-cell lymphoma, mantle cell lymphoma

Abstract

Secondary pancreatic involvement can be seen up to 30% of advance staged non-Hodgkin’s lymphoma cases, but primary pancreatic lymphomas constitute only 1% of extranodal lymphomas. Furthermore, 0.2% of the pancreatic space-occupying lesions are primary pancreatic lymphomas, which usually present as a mass in the head of the pancreas with nonspecific symptoms. Therefore, primary pancreatic lymphomas should be considered as differential diagnosis of pancreatic solid lesions. Herein, we report two cases with different clinical presentation and different course of disease resulting in the diagnosis of primary and metastatic pancreatic lymphoma.

Downloads

Download data is not yet available.

References

Hayat M, Syed TA, Disbrow M, Tran NT, Asad ZU, Tierney WM. Recurrent pancreatitis secondary to diffuse large B cell lymphoma. J Gastrointest Cancer. 2019 Dec;50(4):1009-13. doi: 10.1007/s12029-018-0175-3. DOI: https://doi.org/10.1007/s12029-018-0175-3

Haji AG, Sharma S, Majeed KA, Vijaykumar DK, Pavithran K, Dinesh M. Primary pancreatic lymphoma: report of three cases with review of literature. Indian J Med Paediatr Oncol. 2009 Jan;30(1):20-3. doi: 10.4103/0971-5851.56331. DOI: https://doi.org/10.4103/0971-5851.56331

Behrns KE, Sarr MG, Strickler JG. Pancreatic lymphoma: is it a surgical disease? Pancreas. 1994 Sep;9(5):662-7. DOI: https://doi.org/10.1097/00006676-199409000-00019

Facchinelli D, Sina S, Boninsegna E, Borin A, Tisi MC, Piazza F, et al. Primary pancreatic lymphoma: clinical presentation, diagnosis, treatment, and outcome. Eur J Haematol. 2020 Oct;105(4):468-75. doi: 10.1111/ejh.13468. DOI: https://doi.org/10.1111/ejh.13468

Dunphy L, Abbas SH, Al Shoek I, Al-Salti W. Primary pancreatic lymphoma: a rare clinical entity. BMJ Case Rep. 2020 Jan 5;13(1):e231292. doi: 10.1136/bcr-2019-231292. DOI: https://doi.org/10.1136/bcr-2019-231292

Bosman FT, Carnerio F, Aruban RH, These ND, editors. WHO Classification of Tumours of the Digestive System. 4th ed. In: Lymphoma of the pancreas. Lyon, France: IARC publishing; 2010. 332 p.

Rad N, Khafaf A, Mohammad Alizadeh AH. Primary pancreatic lymphoma: what we need to know. J Gastrointest Oncol. 2017 Aug;8(4):749-57. doi: 10.21037/jgo.2017.06.03. DOI: https://doi.org/10.21037/jgo.2017.06.03

Baysal B, Kayar Y, Ince AT, Arici S, Türkmen I, Şentürk H. Primary pancreatic lymphoma: a rare cause of pancreatic mass. Oncol Lett. 2015 Sep;10(3):1701-3. doi: 10.3892/ol.2015.3412. DOI: https://doi.org/10.3892/ol.2015.3412

Ravi S, Stephen SN, Gochhait D, Potakkat B, Niranjani R, Siddaraju N. Primary pancreatic diffuse large B-cell lymphoma diagnosed by endoscopic ultrasound guided FNAC: a rare entity. Diagn Cytopathol. 2020 Jan;48(1):57-60. doi: 10.1002/dc.24307. DOI: https://doi.org/10.1002/dc.24307

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-49. DOI: https://doi.org/10.3322/caac.21660

Fukuba N, Moriyama I, Ishihara S, Sonoyama H, Yamashita N, Tada Y, et al. Primary pancreatic malignant lymphoma diagnosed from endoscopic ultrasound-guided fine-needle aspiration findings. Intern Med. 2016;55(1):31-5. doi: 10.2169/internalmedicine.55.5749. DOI: https://doi.org/10.2169/internalmedicine.55.5749

Qiu T, Li W, Geng H, Shi S. Clinicopathological characteristics of primary pancreatic lymphoma: report of two cases. Int J Clin Exp Pathol. 2017 Nov 1;10(11):10941-6.

Yu L, Chen Y, Xing L. Primary pancreatic lymphoma: two case reports and a literature review. Onco Targets Ther. 2017 Mar 20;10:1687-94. doi: 10.2147/OTT.S121521. DOI: https://doi.org/10.2147/OTT.S121521

Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004 Jan 1;103(1):275-82. doi: 10.1182/blood-2003-05-1545. DOI: https://doi.org/10.1182/blood-2003-05-1545

Sadaf S, Loya A, Akhtar N, Yusuf MA. Role of endoscopic ultrasound-guided-fine needle aspiration biopsy in the diagnosis of lymphoma of the pancreas: a clinicopathological study of nine cases. Cytopathology. 2017 Dec;28(6):536-41. doi: 10.1111/cyt.12442. DOI: https://doi.org/10.1111/cyt.12442