Evaluation of hospitalized patients with a possible diagnosis of COVID-19

Patients with a possible diagnosis of COVID-19


  • Derya Korkmaz Afyonkarahisar University of Health Sciences Faculty of Medicine, Infectious Diseases and Clinical Microbiology Department, Afyonkarahisar, Turkey ORCID https://orcid.org/0000-0001-7236-2164
  • Petek Konya Afyonkarahisar University of Health Sciences Faculty of Medicine, Infectious Diseases and Clinical Microbiology Department, Afyonkarahisar, Turkey ORCID https://orcid.org/0000-0001-5055-1220
  • Havva Tünay Afyonkarahisar University of Health Sciences Faculty of Medicine, Infectious Diseases and Clinical Microbiology Department, Afyonkarahisar, Turkey ORCID https://orcid.org/0000-0003-4333-082X
  • Oğuzhan Dilek Afyonkarahisar University of Health Sciences Faculty of Medicine, Infectious Diseases and Clinical Microbiology Department, Afyonkarahisar, Turkey ORCID https://orcid.org/0000-0002-8996-3203
  • Neşe Demirtürk Afyonkarahisar University of Health Sciences Faculty of Medicine, Infectious Diseases and Clinical Microbiology Department, Afyonkarahisar, Turkey ORCID https://orcid.org/0000-0002-6186-2494


COVID-19 pandemic, Diagnosis, SARS-CoV-2 virus


Background/Aim: The definitive diagnosis of COVID-19 disease is made by demonstrating the presence of SARS-CoV-2 in nasopharyngeal swab samples. In patients who present with COVID-19-like symptoms but are found to be PCR negative, lung tomography, physical examination, and specific laboratory findings can guide diagnosis and treatment. This study aims to retrospectively evaluate the clinical, laboratory, and radiological findings of patients who presented with Covid-19-like symptoms. but were found to be PCR negative.

Methods: This study was planned as a retrospective cohort study. Patients hospitalized in the pandemic service of Afyonkarahisar Health Sciences University between 19 March and 30 September 2020 - who were PCR negative and defined as possible cases through diagnosis, treatment, and follow-up guidelines of the Republic of Turkey Ministry of Health, were included. Of these patients, those without radiological pulmonary involvement were defined as group A, and those with radiological pulmonary involvement were defined as group B. Clinical and laboratory findings of both groups were evaluated and compared.

Results: In the lung tomographic examination of 238 patients in the study, 16.4% in group A without radiological lung findings and 83.6% in group B with signs of inflammation were identified. While common complaints were high fever and diarrhea in group A, cough and shortness of breath were significantly higher in group B. The most common comorbidities in both groups were hypertension and diabetes, respectively, while hypertension was found to be significantly higher in group B. There was no mortality in any patient without lung involvement, but there was no significant difference between groups in terms of mortality.

Conclusion: These techniques can be used in PCR-negative patients presenting with COVID-19, for an estimation of patients with a severe prognosis with pulmonary tomography findings, symptoms, laboratory results, and accompanying disease at the time of admission. Determining parameters that identify at-risk patients during the early period may contribute to improving patient management and the appropriate use of limited resources.


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Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F, et al. COVID-19 diagnosis and management: a comprehensive review. J Intern Med. 2020;288:192–206. DOI: https://doi.org/10.1111/joim.13091

Erensoy S. SARS-CoV-2 and microbiological diagnostic dynamics in COVID-19 pandemic. Mikrobiyol Bul. 2021;54:497–509. DOI: https://doi.org/10.5578/mb.69839

Atsawarungruangkit A, Yuan J, Kodama T, Cheng MT, Mansouri M, Han B, et al. Evolving global and national criteria for identifying a suspected case of COVID-19. J Int Med Res. 2020;48:1-22. DOI: https://doi.org/10.21203/rs.3.rs-20457/v1

Hu L, Wang C. Radiological role in the detection, diagnosis and monitoring for the coronavirus disease 2019 (COVID-19). Eur Rev Med Pharmacol Sci. 2020;24:4523–28.

Kaya F, Konya PŞ, Demirel E, Demirtürk N, Orhan S, Ufuk F. Visual and quantitative assessment of COVID-19 pneumonia on chest CT: The relationship with disease severity and clinical findings. Curr Med Imaging. 2021;17:1–9. DOI: https://doi.org/10.2174/1573405617666210215142528

T.C. Sağlık Bakanlığı Halk Sağlığı Genel Müdürlüğü. COVID-19 (SARS-CoV-2 Enfeksiyonu) Temaslı Takibi, Salgın Yönetimi, Evde Hasta İzlemi ve Filyasyon. Available from: https://covid19.saglik.gov.tr/Eklenti/38673/0/covid-19rehberitemaslitakibievdehastaizlemivefilyasyonpdf.pdf. Accessed date: 15 October 2020

IDSA Guidelines on the treatment and management of patiens with COVID-19. Available from: https://www.idsociety.org/practice-guideline/covid-19-guideline-treatment-and-management/ Accessed date: 10 August 2021

Simpson S, Kay FU, Abbara S, Bhalla S, Chung JH, Chung M, et al. Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA - Secondary Publication. J Thorac Imaging. 2020;35:219–27. DOI: https://doi.org/10.1097/RTI.0000000000000524

Rona G, Arifoğlu M, Voyvoda N, Batırel A. Should CT be used for the diagnosis of RT-PCR-negative suspected COVID-19 patients? Clin Respir J. 2021;15:491–498. DOI: https://doi.org/10.1111/crj.13332

Marin GB, Aghagoli G, Lavine K, Lanbo Y, Siff EJ, Chiang SS, et al. Predictors of COVID-19 severity: A literature review. Rev Med Virol. 2021;31:1–10. DOI: https://doi.org/10.1002/rmv.2146

CDC. Coronavirus Disease 2019 (COVID-19). Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/people-with-medical-conditions.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2F. Accessed date: 10 August 2021

Garduño, EH. Obesity is the comorbidity more strongly associated for Covid-19 in Mexico. A case-control study. Obes Res Clin Pract. 2020;14:375–9. DOI: https://doi.org/10.1016/j.orcp.2020.06.001

Lagadinou M, Solomou EE, Zareifopoulos N, Marangos M, Gogos C, Velissaris D. Prognosis of COVID-19: Changes in laboratory parameters. Infez Med. 2020;28:89–95.

Ayanian S, Reyes J, Lynn L, Teufel K. The association between biomarkers and clinical outcomes in novel coronavirus pneumonia in a US cohort. Biomark Med. 2020;14:1091–7. DOI: https://doi.org/10.2217/bmm-2020-0309

Bastug A, Bodur H, Erdogan S, Gokcinar D, Kazancioglu S, Kosovali BD, et al. Clinical and laboratory features of COVID-19: Predictors of severe prognosis. Int Immunopharmacol. 2020;88:106950. DOI: https://doi.org/10.1016/j.intimp.2020.106950

Gavriatopoulou M, Ntanasis-Stathopoulos I, Korompoki E, Fotiou D, Migkou M, Tzanninis IG, et al. Emerging treatment strategies for COVID-19 infection. Clin Exp Med. 2021;21:167–79. DOI: https://doi.org/10.1007/s10238-020-00671-y

Okumuş N, Demirtürk N, Çetinkaya RA, Güner R, Avcı İY, Orhan S, et al. Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients. BMC Infect Dis 2021;21:1–11. DOI: https://doi.org/10.1186/s12879-021-06104-9

Koçak A, Coşgun A, Karamanlıoğlu D, Türkkanı MH. The effects of hydroxychloroquine and azithromycin combination therapy on QRS wave in COVID-19 patients. J Surg Med. 2022;6(4):483-7. DOI: https://doi.org/10.28982/josam.985876

Dabbous HM, Abd-Elsalam S, El-Sayed MH, Sherief AF, Ebeid FFS, Ghafar MSAE, et al. Efficacy of favipiravir in COVID 19 treatment: a multi-center randomized study. Arch Virol. 2021;166:949–54. DOI: https://doi.org/10.1007/s00705-021-04956-9

Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, et al. Surviving Sepsis Campaign : Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). Critical Care Medicine. 2020;30:1–32. DOI: https://doi.org/10.1097/CCM.0000000000004363

Jiang B, Wei H. Oxygen therapy strategies and techniques to treat hypoxia in COVID-19 patients. Eur Rev Med Pharmacol Sci. 2020;24:10239–46.

Matta S, Chopra KK, Arora VK. Morbidity and mortality trends of Covid 19 in top 10 countries. Indian J Tuberc. 2020;67:S167–72. DOI: https://doi.org/10.1016/j.ijtb.2020.09.031






Research Article

How to Cite

Korkmaz D, Konya P, Tünay H, Dilek O, Demirtürk N. Evaluation of hospitalized patients with a possible diagnosis of COVID-19: Patients with a possible diagnosis of COVID-19. J Surg Med [Internet]. 2022 Jul. 29 [cited 2024 Jun. 22];6(7):653-7. Available from: https://jsurgmed.com/article/view/1110061