Dietary polyphenols in the treatment of inflammatory bowel diseases: Polyphenols in IBD treatment

Açelya Gül  Koyuncu; Elvan Yılmaz  Akyüz

doi:10.28982/josam.1060925

Authors

Açelya Gül Koyuncu Yeditepe University, Faculty of Health Sciences, Department of Nutrition and Dietetics İstanbul, Turkey https://orcid.org/0000-0003-1776-1829
Elvan Yılmaz Akyüz University of Health Sciences, Hamidiye Faculty of Health Sciences, Department of Nutrition and Dietetics, İstanbul, Turkey https://orcid.org/0000-0002-1878-9412

DOI:

https://doi.org/10.28982/josam.1060925

Keywords:

Inflammatory bowel diseases, Ulcerative colitis, Crohn's disease, Polyphenols

Abstract

Ulcerative colitis and Crohn's disease, caused by chronic inflammation in the digestive tract, are inflammatory bowel diseases and have similar symptoms. Abnormal immune responses play a pretty important role in the pathogenesis of the disease. Proinflammatory mediators trigger inflammation, stimulate cell signaling molecules, and induce disease onset. Corticosteroids, anti-tumor necrosis factor-α antibodies, and immunosuppressants are some drugs used to treat the disease. However, these drugs have some side effects. In addition, surgical methods might be used in the treatment, but these methods may have some complications. Due to the negative impact on treatment options, alternative methods for reliable, inexpensive, and effective treatment are being sought. Secondary plant compounds with an aromatic or phenolic ring structure, so-called polyphenols or phenolic compounds, may modulate cellular signaling pathways and reduce intestinal inflammation due to their antioxidant and anti-inflammatory effects. Polyphenols may be evaluated as alternative methods for inflammatory bowel disease based on these properties. This review aims to investigate the effect of some polyphenols on inflammatory bowel disease.

Downloads

Download data is not yet available.

References

Arikan T, Akcan A, Dönder Y, Yilmaz Z, Sözüer E, Öz B, et al. Effects of erythropoietin on bacterial translocation in a rat model of experimental colitis. Turkish J Surg. 2019;35:202–9. DOI: https://doi.org/10.5578/turkjsurg.4272

Eichele DD, Young R. Medical Management of Inflammatory Bowel Disease. Surgical Clinics of North America. 2019;99:1223–35. DOI: https://doi.org/10.1016/j.suc.2019.08.011

Fallahi F, Borran S, Ashrafizadeh M, Zarrabi A, Pourhanifeh MH, Khaksary Mahabady M, et al. Curcumin and inflammatory bowel diseases: From in vitro studies to clinical trials. Mol Immunol. 2021;130 November 2020:20–30. DOI: https://doi.org/10.1016/j.molimm.2020.11.016

Dönder Y, Arikan TB, Baykan M, Akyüz M, Öz AB. Effects of quercitrin on bacterial translocation in a rat model of experimental colitis. Asian J Surg. 2018;41:543–50. DOI: https://doi.org/10.1016/j.asjsur.2017.12.002

Guan Q. A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease. J Immunol Res. 2019;2019. DOI: https://doi.org/10.1155/2019/7247238

Kobayashi T, Siegmund B, Le Berre C, Wei SC, Ferrante M, Shen B, et al. Ulcerative colitis. Nat Rev Dis Prim. 2020;6. DOI: https://doi.org/10.1038/s41572-020-0205-x

Mak WY, Zhao M, Ng SC, Burisch J. The epidemiology of inflammatory bowel disease: East meets west. J Gastroenterol Hepatol. 2020;35:380–9. DOI: https://doi.org/10.1111/jgh.14872

Bentham J, Di Cesare M, Bilano V, Bixby H, Zhou B, Stevens GA, et al. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet. 2017;390:2627–42. DOI: https://doi.org/10.1016/S0140-6736(17)32129-3

Guilherme Piovezani Ramos M and K. Mechanisms of Disease: Inflammatory Bowel Diseases. 2019;94:155–66. DOI: https://doi.org/10.1016/j.mayocp.2018.09.013

Limdi JK. Dietary practices and inflammatory bowel disease. Indian J Gastroenterol. 2018;37:284–92. DOI: https://doi.org/10.1007/s12664-018-0890-5

Larussa T, Imeneo M, Luzza F. Potential role of nutraceutical compounds in inflammatory bowel disease. World J Gastroenterol. 2017;23:2483–92. DOI: https://doi.org/10.3748/wjg.v23.i14.2483

Arya VS, Kanthlal SK, Linda G. The role of dietary polyphenols in inflammatory bowel disease: A possible clue on the molecular mechanisms involved in the prevention of immune and inflammatory reactions. J Food Biochem. 2020;44:1–17. DOI: https://doi.org/10.1111/jfbc.13369

Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease. J Med Life. 2019;12:113–22.

Flynn S, Eisenstein S. Inflammatory Bowel Disease Presentation and Diagnosis. Surg Clin North Am. 2019;99:1051–62. DOI: https://doi.org/10.1016/j.suc.2019.08.001

Baumgart DC, Sandborn WJ, Veauthier B, Hornecker JR. P661. 2018;380:1590–605. DOI: https://doi.org/10.1016/S0140-6736(12)60026-9

Day AS, Leach ST, Lemberg DA. An update on diagnostic and prognostic biomarkers in inflammatory bowel disease. Expert Rev Mol Diagn. 2017;17:835–43. DOI: https://doi.org/10.1080/14737159.2017.1364160

Wehkamp J, Götz M, Herrlinger K, Steurer W, Stange EF. Chronisch entzündliche Darmerkrankungen: Morbus Crohn und Colitis ulcerosa. Dtsch Arztebl Int. 2016;113:72–81.

Jeong DY, Kim S, Son MJ, Son CY, Kim JY, Kronbichler A, et al. Induction and maintenance treatment of inflammatory bowel disease: A comprehensive review. Autoimmun Rev. 2019;18:439–54. DOI: https://doi.org/10.1016/j.autrev.2019.03.002

Ferrari L, Krane MK, Fichera A. Inflammatory bowel disease surgery in the biologic era. World J Gastrointest Surg. 2016;8:363. DOI: https://doi.org/10.4240/wjgs.v8.i5.363

Cohen RD, Yu AP, Wu EQ, Xie J, Mulani PM, Chao J. Systematic review: the costs of ulcerative colitis in Western countries. Aliment Pharmacol Ther. 2010;31:693–707. DOI: https://doi.org/10.1111/j.1365-2036.2010.04234.x

Uranga JA, López-Miranda V, Lombó F, Abalo R. Food, nutrients and nutraceuticals affecting the course of inflammatory bowel disease. Pharmacol Reports. 2016;68:816–26. DOI: https://doi.org/10.1016/j.pharep.2016.05.002

Martin DA, Bolling BW. A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases. Food Funct. 2015;6:1773–86. DOI: https://doi.org/10.1039/C5FO00202H

Kaulmann A, Bohn T. Bioactivity of Polyphenols: Preventive and Adjuvant Strategies toward Reducing Inflammatory Bowel Diseases - Promises, Perspectives, and Pitfalls. Oxid Med Cell Longev. 2016;2016 c. DOI: https://doi.org/10.1155/2016/9346470

Lu Y, Zamora-Ros R, Chan S, Cross AJ, Ward H, Jakszyn P, et al. Dietary Polyphenols in the Aetiology of Crohn’s Disease and Ulcerative Colitis-A Multicenter European Prospective Cohort Study (EPIC). Inflamm Bowel Dis. 2017;23:2072–82. DOI: https://doi.org/10.1097/MIB.0000000000001108

Fan FY, Sang LX, Jiang M, McPhee DJ. Catechins and their therapeutic benefits to inflammatory bowel disease. Molecules. 2017;22. DOI: https://doi.org/10.3390/molecules22030484

Scarano A, Butelli E, De Santis S, Cavalcanti E, Hill L, De Angelis M, et al. Combined Dietary Anthocyanins, Flavonols, and Stilbenoids Alleviate Inflammatory Bowel Disease Symptoms in Mice. Front Nutr. 2018;4 January:1–10. DOI: https://doi.org/10.3389/fnut.2017.00075

Tian T, Wang Z, Zhang J. Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies. Oxid Med Cell Longev. 2017;2017. DOI: https://doi.org/10.1155/2017/4535194

Vezza T, Rodríguez-Nogales A, Algieri F, Utrilla MP, Rodriguez-Cabezas ME, Galvez J. Flavonoids in inflammatory bowel disease: A review. Nutrients. 2016;8. DOI: https://doi.org/10.3390/nu8040211

Rogler G. Where are we heading to in pharmacological IBD therapy? Pharmacol Res. 2015;100:220–7. DOI: https://doi.org/10.1016/j.phrs.2015.07.005

Zhang L, Hui XUE, Zhao G, Qiao C, Xiaomei SUN, Pang C, et al. Curcumin and resveratrol suppress dextran sulfate sodium‑induced colitis in mice. Mol Med Rep. 2019;19:3053–60. DOI: https://doi.org/10.3892/mmr.2019.9974

Yildiz G, Yildiz Y, Ulutas P, Yaylali A, Ural M. Resveratrol Pretreatment Ameliorates TNBS Colitis in Rats. Recent Pat Endocr Metab Immune Drug Discov. 2015;9:134–40. DOI: https://doi.org/10.2174/1872214809666150806105737

Samsamikor M, Daryani NE, Asl PR, Hekmatdoost A. Resveratrol Supplementation and Oxidative/Anti-Oxidative Status in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study. Arch Med Res. 2016;47:304–9. DOI: https://doi.org/10.1016/j.arcmed.2016.07.003

Wang Y, Wang Y, Shen W, Wang Y, Cao Y, Nuerbulati N, et al. Grape Seed Polyphenols Ameliorated Dextran Sulfate Sodium-Induced Colitis via Suppression of Inflammation and Apoptosis. Pharmacology. 2020;105:9–18. DOI: https://doi.org/10.1159/000501897

Nunes C, Almeida L, Barbosa RM, Laranjinha J. Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation. In: Food and Function. Royal Society of Chemistry; 2017. p. 387–96. DOI: https://doi.org/10.1039/C6FO01529H

Baykalir BG, Aksit D, Dogru MS, Yay AH, Aksit H, Seyrek K, et al. Lycopene ameliorates experimental colitis in rats via reducing apoptosis and oxidative stress. Int J Vitam Nutr Res. 2016;86:27–35. DOI: https://doi.org/10.1024/0300-9831/a000280

Hong Z, Piao M. Effect of Quercetin Monoglycosides on Oxidative Stress and Gut Microbiota Diversity in Mice with Dextran Sodium Sulphate-Induced Colitis. Biomed Res Int. 2018;2018. DOI: https://doi.org/10.1155/2018/8343052

Shah TA, Parikh M, Patel K V., Patel KG, Joshi CG, Gandhi TR. Evaluation of the effect of Punica granatum juice and punicalagin on NFκB modulation in inflammatory bowel disease. Mol Cell Biochem. 2016;419:65–74. DOI: https://doi.org/10.1007/s11010-016-2750-x

Joo M, Kim HS, Kwon TH, Palikhe A, Zaw TS, Jeong JH, et al. Anti-inflammatory effects of flavonoids on TNBS-induced colitis of rats. Korean J Physiol Pharmacol. 2015;19:43–50. DOI: https://doi.org/10.4196/kjpp.2015.19.1.43

Du Y, Ding H, Vanarsa K, Soomro S, Baig S, Hicks J, et al. Low dose epigallocatechin gallate alleviates experimental colitis by subduing inflammatory cells and cytokines and improving intestinal permeability. Nutrients. 2019;11. DOI: https://doi.org/10.3390/nu11081743

Zhao L, Xiao HT, Mu HX, Huang T, Lin ZS, Zhong LLD, et al. Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice. Molecules. 2017;22. DOI: https://doi.org/10.3390/molecules22071218

Khodayar B, Farzaei MH, Hossein Abdolghaffari A, Bahramsoltani R, Baeeri M, Sabbagh Ziarani F, et al. The Protective Effect of the Gallic Acid Against TNBS-induced Ulcerative Colitis in Rats: Role of Inflammatory Parameters. Islamic Republic of Iran Medical Council; 2018.