The link between serum ACKR2 level and Crohn's Disease and its activity

Sami Çifçi; Mehmet Bayram; Kader Irak; Nergis Ekmen; Gülsen Şener; Hadi Sasani

doi:10.28982/josam.1003024

Authors

Sami Çifçi Basaksehir Cam and Sakura City Hospital, Department of Gastroenterology, https://orcid.org/0000-0003-0226-6825
Mehmet Bayram SBU Istanbul Kanuni Sultan Süleyman Training and Research Hospital, Department of Gastroenterology https://orcid.org/0000-0003-2366-5286
Kader Irak Basaksehir Cam and Sakura City Hospital, Department of Gastroenterology https://orcid.org/0000-0002-0019-3207
Nergis Ekmen Gazi University Medical Faculty, Department of Gastroenterology https://orcid.org/0000-0002-7921-3169
Gülsen Şener Basaksehir Cam and Sakura City Hospital, Department of Biochemistry https://orcid.org/0000-0002-2006-2175
Hadi Sasani Tekirdag Namık Kemal University, Faculty of Medicine, Department of Radiology https://orcid.org/0000-0001-6236-4123

DOI:

https://doi.org/10.28982/josam.1003024

Keywords:

ACKR2, Chemokine, Crohn’s disease, Inflammation

Abstract

Backgrounds/Aim: Atypical chemokine receptor (ACKR) family suppresses chemokine response and keeps the inflammatory state under control. This study investigated ACKR2 serum levels, which are thought to have an effect on the extreme inflammatory state in Crohn's disease (CD). Methods: Active and newly diagnosed Crohn's patients under treatment and a healthy control group were included in this prospective case-control study. Patients under the age of 18 years and those with Crohn's disease in remission were excluded. Clinical, demographic, laboratory parameters and serum ACKR2 levels of the patients were examined. Disease activity was evaluated using the simplified endoscopic score for Crohn’s disease (SES-CD) and Crohn’s disease activity index (CDAI) index. The relationship between disease activity and serum ACKR2 was evaluated using the Spearman correlation analysis. Results: A total of 119 subjects (66 CD patients and 53 healthy controls) were included in the study. Serum ACKR2 level was significantly lower in the CD group (4.80 ng/mL) compared to the control group (11.15 ng/mL) (P<0.001). In the correlation analysis between ACKR2 level and disease activity indicators, there was a weak positive correlation with SES-CD and CDAI (r = 0.350 P=0.004, r = 0.252, P=0.041, respectively). Conclusion: Our data show that the ACKR2 level in active CD is quite low compared to the control group. Despite the increase in disease activity, it is not upregulated at a sufficient level and may have adverse effects on the progression of the disease.

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