The link between serum ACKR2 level and Crohn's Disease and its activity
Keywords:ACKR2, Chemokine, Crohn’s disease, Inflammation
Backgrounds/Aim: Atypical chemokine receptor (ACKR) family suppresses chemokine response and keeps the inflammatory state under control. This study investigated ACKR2 serum levels, which are thought to have an effect on the extreme inflammatory state in Crohn's disease (CD). Methods: Active and newly diagnosed Crohn's patients under treatment and a healthy control group were included in this prospective case-control study. Patients under the age of 18 years and those with Crohn's disease in remission were excluded. Clinical, demographic, laboratory parameters and serum ACKR2 levels of the patients were examined. Disease activity was evaluated using the simplified endoscopic score for Crohn’s disease (SES-CD) and Crohn’s disease activity index (CDAI) index. The relationship between disease activity and serum ACKR2 was evaluated using the Spearman correlation analysis. Results: A total of 119 subjects (66 CD patients and 53 healthy controls) were included in the study. Serum ACKR2 level was significantly lower in the CD group (4.80 ng/mL) compared to the control group (11.15 ng/mL) (P<0.001). In the correlation analysis between ACKR2 level and disease activity indicators, there was a weak positive correlation with SES-CD and CDAI (r = 0.350 P=0.004, r = 0.252, P=0.041, respectively). Conclusion: Our data show that the ACKR2 level in active CD is quite low compared to the control group. Despite the increase in disease activity, it is not upregulated at a sufficient level and may have adverse effects on the progression of the disease.
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