Yıl 2021, Cilt 5 , Sayı 2, Sayfalar 163 - 167 2021-02-01

Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma

Ahmet DİRİCAN [1] , Ferhat EKİNCİ [2] , Atike Pinar ERDOĞAN [3] , Gamze GÖKSEL [4]


Background/Aim: The importance of prognostic markers in the treatment and follow-up of metastatic renal cell carcinoma is gradually increasing. Currently used markers do not meet the exact needs in this regard. In this study, we evaluated the predictive and prognostic values of inflammatory prognostic index (IPI) scoring in metastatic Renal cell carcinoma (RCC) patients. In IPI scoring, we used four biochemical parameters related to inflammation, including albumin, CRP, neutrophils, and lymphocytes. Methods: Medical records of fifty-seven patients with RCC treated in Celal Bayar University Medical Faculty Hospital Medical Oncology Clinic between February 2012 and April 2019 were retrospectively reviewed. The IPI was calculated as C-reactive protein × NLR (neutrophil/lymphocyte ratio)/serum albumin. Univariate and multivariate analyses were performed to assess the prognostic value of relevant factors. Results: The cut-off value for IPI in predicting mortality was 1.03 according to ROC curve analysis. Median OS of the patients with IPI ≥1.03 was 8 months (95 %Cl 3-10.9). The relationship between overall survival and IPI score was remarkable. According to this analysis, comorbidity, metastasis to the lung, liver, lymph nodes, bone, the number of metastatic sites (one metastatic area), high NLR, high IPI were also significantly associated with OS (P<0.05 for each). In multivariate analyses, IPI was an independent prognostic factor in RCC. Patients with high IPI (>1.03) had an increased mortality risk compared to those with low IPI (<1.03) (HR: 8.5; 95 %CI, 2.303-31.42; P<0.001). Comorbidity, lung metastasis, lymph nodes and bone metastasis, high NLR, IMDC risk also independently predicted worse OS in RCC. Conclusion: The relationship between many inflammatory markers, such as NLR and RCC, and overall survival was proven earlier, while the relationship with IPI is discussed for the first time. We would like to discuss the findings we obtained in our study in the light of other analyses in the literature investigating the relationship between other inflammation markers and RCC. IPI may be an easily accessible and independent prognostic index for RCC patients, and useful for clinical practice.
Renal cell carcinoma, IPI scoring, Overall survival, Neutrophil/lymphocyte ratio, Inflammation mediators, C-reactive protein, Albumin
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Birincil Dil en
Konular Onkoloji
Bölüm Araştırma makalesi
Yazarlar

Orcid: 0000-0001-6992-9289
Yazar: Ahmet DİRİCAN (Sorumlu Yazar)
Kurum: Manisa Celal Bayar Üniversitesi Tıp Fakültesi
Ülke: Turkey


Orcid: 0000-0002-9317-942X
Yazar: Ferhat EKİNCİ
Kurum: Manisa Celal Bayar Üniversitesi Tıp Fakültesi
Ülke: Turkey


Orcid: 0000-0003-4859-7574
Yazar: Atike Pinar ERDOĞAN
Kurum: Manisa Celal Bayar Üniversitesi Tıp Fakültesi
Ülke: Turkey


Orcid: 0000-0002-7991-0036
Yazar: Gamze GÖKSEL
Kurum: Manisa Celal Bayar Üniversitesi Tıp Fakültesi
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 1 Şubat 2021

Bibtex @araştırma makalesi { josam850739, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2021}, volume = {5}, pages = {163 - 167}, doi = {10.28982/josam.850739}, title = {Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma}, key = {cite}, author = {Dirican, Ahmet and Ekinci, Ferhat and Erdoğan, Atike Pinar and Göksel, Gamze} }
APA Dirican, A , Ekinci, F , Erdoğan, A , Göksel, G . (2021). Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma . Journal of Surgery and Medicine , 5 (2) , 163-167 . DOI: 10.28982/josam.850739
MLA Dirican, A , Ekinci, F , Erdoğan, A , Göksel, G . "Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma" . Journal of Surgery and Medicine 5 (2021 ): 163-167 <http://jsurgmed.com/tr/pub/issue/60239/850739>
Chicago Dirican, A , Ekinci, F , Erdoğan, A , Göksel, G . "Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma". Journal of Surgery and Medicine 5 (2021 ): 163-167
RIS TY - JOUR T1 - Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma AU - Ahmet Dirican , Ferhat Ekinci , Atike Pinar Erdoğan , Gamze Göksel Y1 - 2021 PY - 2021 N1 - doi: 10.28982/josam.850739 DO - 10.28982/josam.850739 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 163 EP - 167 VL - 5 IS - 2 SN - -2602-2079 M3 - doi: 10.28982/josam.850739 UR - https://doi.org/10.28982/josam.850739 Y2 - 2021 ER -
EndNote %0 Journal of Surgery and Medicine Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma %A Ahmet Dirican , Ferhat Ekinci , Atike Pinar Erdoğan , Gamze Göksel %T Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma %D 2021 %J Journal of Surgery and Medicine %P -2602-2079 %V 5 %N 2 %R doi: 10.28982/josam.850739 %U 10.28982/josam.850739
ISNAD Dirican, Ahmet , Ekinci, Ferhat , Erdoğan, Atike Pinar , Göksel, Gamze . "Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma". Journal of Surgery and Medicine 5 / 2 (Şubat 2021): 163-167 . https://doi.org/10.28982/josam.850739
AMA Dirican A , Ekinci F , Erdoğan A , Göksel G . Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma. J Surg Med. 2021; 5(2): 163-167.
Vancouver Dirican A , Ekinci F , Erdoğan A , Göksel G . Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma. Journal of Surgery and Medicine. 2021; 5(2): 163-167.
IEEE A. Dirican , F. Ekinci , A. Erdoğan ve G. Göksel , "Inflammatory prognostic index score as a new parameter predicting overall survival in renal cell carcinoma", Journal of Surgery and Medicine, c. 5, sayı. 2, ss. 163-167, Şub. 2021, doi:10.28982/josam.850739