Year 2020, Volume 4 , Issue 11, Pages 970 - 973 2020-11-01

Lopinavir/ritonavir ve favipiravir ile tedavi edilen ağır olmayan COVID-19 pnömoni hastalarının karşılaştırılması
Comparison of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and favipiravir

Omer AYTEN [1] , Bengü ŞAYLAN [2]


Amaç: Günümüzde COVID-19 için kanıtlanmış bir medikal tedavi yoktur. Çalışmamızda ağır seviyeli olmayan COVID-19 pnömoni hastalarında LPV/r ve FVR tedavilerinin etkinliğini değerlendirerek, LPV/r ile FVR ile tedavi edilen hastalar arasındaki klinik sonuçları karşılaştırmayı amaçladık. Yöntemler: Bu çalışma retrospektif bir kohort çalışmasıdır. Lopinavir/ritonavir ve FVR ile tedavi edilen ağır seviyeli olmayan COVID-19 pnömoni hastalarının verileri incelendi. Bulgular: 33'ü (%36,2) LPV/r ve 58'i (%63,8) FVR ile tedavi edilen, toplam 91 ağır seviyeli olmayan COVID-19 pnömoni hastası çalışmaya dahil edildi. LPV/r grubunun yaş ortalaması 53,1 (13), FVR grubunun yaş ortalaması 57,2 (17,4) idi (P=0,24). Her iki grup arasında komorbidite varlığı açısından istatiksel olarak anlamlı fark yoktu (P=0,06). FVR hastalarının LPV/r hastalarına göre radyolojik ağırlık skoru daha yüksekti ancak bu istatistiksel olarak anlamlı değildi (sırasıyla 8,67 (3,7) ve 7,66 (3,22), P=0,2). FVR hastalarının başvuru esnasındaki SpO2 seviyeleri LPV/r hastalarına göre daha düşük, CRP seviyeleri daha yüksekti (sırasıyla 92,22 (2,8) ve 97,87 (2,05), P<0,001, 75,42 (62) ve 45,42 (49,92), P=0,02). FVR hastalarında LPV /r hastalarına göre ateşin düşme süresi daha kısa idi (sırasıyla 2,7 (0,9) ve 4 (1), P<0,001). FVR kullanan hastalarda tedavi sonrasında LPV/r kullanan hastalara göre Nötrofil, Lenfosit, N/L oranı ve D-Dimer seviyelerinin daha fazla düştüğü saptandı (sırasıyla P=0,01, <0,001, 0,001, <0,001). Sonuç: FVR kullanan hastaların, başvuru esnasında daha düşük oksijen saturasyonlarına, daha yaygın radyolojik tutulumlarına ve daha yüksek CRP seviyelerine sahip olmasına rağmen LPV/r kullanan hastalara göre laboratuvar parametrelerinin düzelmesinde ve ateşin kontrol altına alınmasında daha etkili olduğunu saptadık. COVID-19 hastalarında LPV/r ve FVR tedavilerinin etkinliği üzerine daha fazla çalışmaya ihtiyaç vardır.
Aim: There is no proven medical treatment for COVID-19 to date. We aimed to evaluate the effectiveness of LPV/r and FVR treatments in non-severe COVID-19 pneumonia patients and compare the clinical outcomes. Methods: In this retrospective cohort study, the data of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and FVR were analyzed. Results: A total of 91 non-severe COVID-19 patients, 33 (36.2%) treated with LPV/r and 58 (63.8%) treated with FVR, were included in the study. The mean ages of the LPV/r group and FVR group were 53.1 (13) years and 57.2 (17.44) years, respectively (P=0.24). There was no statistically significant difference between the two groups in terms of comorbidities (P=0.06). FVR patients had higher radiological weight scores than LPV/r patients, but this was not statistically significant (8.67 (3.7) vs 7.66 (3.22) P=0.2, respectively). While SpO2 levels of FVR patients at the time of admission were lower than those of LPV/r patients, CRP levels were higher (92.22 (2.8) vs 97.87 (2.05), P<0.001, respectively and 75.42 (62) vs 45.42 (49.92), P=0.02, respectively). FVR patients had a shorter fever regression time than LPV/r patients (2.7 (0.9) vs 4 (1), P<0.001, respectively). Post-treatment neutrophil, lymphocyte, N/L ratio and D-Dimer levels decreased more in FVR group compared to the LPV/r group (P=0.01, <0.001, 0.001, <0.001, respectively). Conclusion: Although non-severe COVID-19 patients using FVR had lower oxygen saturations, more widespread radiological involvement, and higher CRP levels at admission, we found that FVR was more effective in improving laboratory parameters and controlling fever than LPV/r treatment. The efficacy of lopinavir/ritonavir and FVR warrants further verification by future, larger studies.
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Primary Language en
Subjects Respiratory System
Journal Section Research article
Authors

Orcid: 0000-0002-2275-4378
Author: Omer AYTEN (Primary Author)
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0002-5922-0847
Author: Bengü ŞAYLAN
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ
Country: Turkey


Dates

Publication Date : November 1, 2020

Bibtex @research article { josam795283, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {970 - 973}, doi = {10.28982/josam.795283}, title = {Comparison of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and favipiravir}, key = {cite}, author = {Ayten, Omer and Şaylan, Bengü} }
APA Ayten, O , Şaylan, B . (2020). Comparison of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and favipiravir . Journal of Surgery and Medicine , 4 (11) , 970-973 . DOI: 10.28982/josam.795283
MLA Ayten, O , Şaylan, B . "Comparison of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and favipiravir" . Journal of Surgery and Medicine 4 (2020 ): 970-973 <http://jsurgmed.com/en/pub/issue/57748/795283>
Chicago Ayten, O , Şaylan, B . "Comparison of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and favipiravir". Journal of Surgery and Medicine 4 (2020 ): 970-973
RIS TY - JOUR T1 - Comparison of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and favipiravir AU - Omer Ayten , Bengü Şaylan Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.795283 DO - 10.28982/josam.795283 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 970 EP - 973 VL - 4 IS - 11 SN - -2602-2079 M3 - doi: 10.28982/josam.795283 UR - https://doi.org/10.28982/josam.795283 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Comparison of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and favipiravir %A Omer Ayten , Bengü Şaylan %T Comparison of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and favipiravir %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 11 %R doi: 10.28982/josam.795283 %U 10.28982/josam.795283
ISNAD Ayten, Omer , Şaylan, Bengü . "Comparison of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and favipiravir". Journal of Surgery and Medicine 4 / 11 (November 2020): 970-973 . https://doi.org/10.28982/josam.795283
AMA Ayten O , Şaylan B . Comparison of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and favipiravir. J Surg Med. 2020; 4(11): 970-973.
Vancouver Ayten O , Şaylan B . Comparison of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and favipiravir. Journal of Surgery and Medicine. 2020; 4(11): 970-973.
IEEE O. Ayten and B. Şaylan , "Comparison of non-severe COVID-19 pneumonia patients treated with lopinavir/ritonavir and favipiravir", Journal of Surgery and Medicine, vol. 4, no. 11, pp. 970-973, Nov. 2020, doi:10.28982/josam.795283