Year 2020, Volume 4 , Issue 10, Pages 861 - 864 2020-10-01

Evaluation of perinatal arterial ischemic stroke patients: A single center experience
Perinatal arteriyel iskemik inme hastalarının değerlendirilmesi: Tek merkez deneyimi

Ozan KOÇAK [1]


Aim: Perinatal arterial ischemic stroke (PAIS) is the one of the frequent causes of morbidity and neurologic disability, such as unilateral cerebral palsy (UCP), epilepsy and neurodevelopmental deficiencies. The aim of this study is to determine the clinical characteristics, risk factors and long term outcomes of PAIS patients. Methods: This retrospective cohort study was conducted with 49 PAIS patients who were followed up in the Pediatric Neurology Department between January 2009 and September 2015. Clinical data including demographic features, gestational history, age at diagnosis, initial clinical presentation, brain MRI features, perinatal risk factors and long-term outcome were collected from patient files. Results: The study group comprised 30 females and 19 males with a mean age of 6.3 (4.5) years. Twin pregnancy (6.1%), intrauterine growth retardation (IUGR) (8.2%), peripartum asphyxia (8.2%) and presentation abnormality (6.1%) were the most common maternal / neonatal risk factors. The most common prothrombotic risk factors were MTHFR mutations (42.85%), followed by FVL mutations (16.32%). The epilepsy rate was 73.3%, 6.4% of which had refractory epilepsy. All patients had UCP. Conclusions: Risk factors and their roles in development of PAIS have not been fully established. According to this study, most of the PAIS patients have at least one or more maternal, neonatal or prothrombotic risk factors, and all patients have motor and cognitive impairment related with PAIS. Multi-center prospective studies with more cases are needed to fully enlighten the causes of this disease and to develop preventive measures.
Amaç: Perinatal arteriyel iskemik strok (PAIS), unilateral serebral palsi (UCP), epilepsi ve nörogelişimsel bozukluklar gibi morbidite ve nörolojik hastalığın sık nedenlerinden biridir. Bu çalışmanın amacı, PAIS hastalarının klinik özelliklerini, risk faktörlerini ve uzun vadeli sonuçlarını belirlemektir. Yöntemler: Bu retrospektif kohort çalışma, Ocak 2009-Eylül 2015 tarihleri arasında Çocuk Nörolojisi Bölümünde takip edilen 49 PAIS hastası ile yapılmıştır. Demografik özellikler, gebelik öyküsü, tanı yaşı, ilk klinik bulgu, beyin MRG bulguları, perinatal risk faktörlerini ve uzun vadeli sonuçları hasta dosyalarından toplandı. Bulgular: Çalışma grubu yaş ortalaması 6,3 (4,5) yıl olan, 30 kadın ve 19 erkekten oluşmuştur. İkiz gebelik (%6,1), intrauterin büyüme geriliği (IUGR) (%8,2), perpartum asfiksi (%8,2) ve prezentasyon anormallikleri (%6,1) en sık görülen maternal / neonatal risk faktörleri idi. En yaygın protrombotik risk faktörleri ise MTHFR mutasyonları (%42,85) ve FVL mutasyonlarıydı (%16,32). Hastalardaki epilepsi oranı %73,3 olarak saptandı ve bu hastaların % 6,4'ünde dirençli epilepsi vardı. Tüm hastalar unilateral serebral palsi tanısı ile izleniyordu. Sonuç: PAIS risk faktörleri ve bu risk faktörlerinin PAIS gelişimindeki rolleri tam olarak belirlenmemiştir. Bu çalışmaya göre, PAIS hastalarının çoğunda en az bir veya daha fazla maternal, neonatal veya protrombotik risk faktörü bulunmaktadır. Ve tüm hastalarda PAIS ile ilgili motor ve bilişsel bozukluk vardır. Bu hastalığın nedenlerini tam olarak aydınlatmak ve önleyici tedbirler geliştirebilmek için daha fazla vaka içeren çok merkezli prospektif çalışmalara ihtiyaç vardır.
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Primary Language en
Subjects Neurosciences, Pediatrics
Journal Section Research article
Authors

Orcid: 0000-0002-2285-7983
Author: Ozan KOÇAK (Primary Author)
Institution: özel
Country: Turkey


Supporting Institution Destekleyen kurum bulunmamaktadır
Dates

Publication Date : October 1, 2020

Bibtex @research article { josam811728, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {861 - 864}, doi = {10.28982/josam.811728}, title = {Evaluation of perinatal arterial ischemic stroke patients: A single center experience}, key = {cite}, author = {Koçak, Ozan} }
APA Koçak, O . (2020). Evaluation of perinatal arterial ischemic stroke patients: A single center experience . Journal of Surgery and Medicine , 4 (10) , 861-864 . DOI: 10.28982/josam.811728
MLA Koçak, O . "Evaluation of perinatal arterial ischemic stroke patients: A single center experience" . Journal of Surgery and Medicine 4 (2020 ): 861-864 <http://jsurgmed.com/en/pub/issue/57049/811728>
Chicago Koçak, O . "Evaluation of perinatal arterial ischemic stroke patients: A single center experience". Journal of Surgery and Medicine 4 (2020 ): 861-864
RIS TY - JOUR T1 - Evaluation of perinatal arterial ischemic stroke patients: A single center experience AU - Ozan Koçak Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.811728 DO - 10.28982/josam.811728 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 861 EP - 864 VL - 4 IS - 10 SN - -2602-2079 M3 - doi: 10.28982/josam.811728 UR - https://doi.org/10.28982/josam.811728 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Evaluation of perinatal arterial ischemic stroke patients: A single center experience %A Ozan Koçak %T Evaluation of perinatal arterial ischemic stroke patients: A single center experience %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 10 %R doi: 10.28982/josam.811728 %U 10.28982/josam.811728
ISNAD Koçak, Ozan . "Evaluation of perinatal arterial ischemic stroke patients: A single center experience". Journal of Surgery and Medicine 4 / 10 (October 2020): 861-864 . https://doi.org/10.28982/josam.811728
AMA Koçak O . Evaluation of perinatal arterial ischemic stroke patients: A single center experience. J Surg Med. 2020; 4(10): 861-864.
Vancouver Koçak O . Evaluation of perinatal arterial ischemic stroke patients: A single center experience. Journal of Surgery and Medicine. 2020; 4(10): 861-864.
IEEE O. Koçak , "Evaluation of perinatal arterial ischemic stroke patients: A single center experience", Journal of Surgery and Medicine, vol. 4, no. 10, pp. 861-864, Oct. 2020, doi:10.28982/josam.811728