Year 2020, Volume 4 , Issue 1, Pages 25 - 28 2020-01-02

Tekrarlayan gebelik kaybını öngörmede over rezerv testlerinin kullanılması
Ovarian reserve testing in the prediction of recurrent pregnancy loss

Sadik KÜKRER [1] , Sefa ARLIER [2] , Seyfettin Senih KARAMAN [3]


Amaç: Üreme çağındaki kadınlarının yaklaşık %1-2'si tekrarlayan gebelik kaybı (RPL) ile karşı karşıyadır. Tekrarlayan gebelik kaybının öngörülmesinde yumurtalık rezerv testi genellikle yapılmaz. Bu çalışmamızda Antimüllerian hormon, follikül stimulant hormon, Lüteinizan hormon, Estradiol ve Bazal follikül sayısının tekrarlayan gebelik kabı olan ve olmayan hastalar arasında farklı olup olmadığının değerlendirilmesi amaçlanmıştır.

Yöntemler: 2 yıllık sürede tekrarlayan gebelik kaybı tanısı konulan, yaşları 17-37 yaş arası 370 hasta telefonla aranarak ayrıntılı sorgulama sonucu çalışma kriterlerine uyan ve sözlü onamları alınan 40 hasta tekrar değerlendirilmek üzere mensrüel siklusun 3. günü jinekoloji polikiniğe davet edildi. Çalışma grubu olarak alınan hastalarla aynı gün jinekoloji polikliniğine başvuran benzer demoğrafik özellikteki çalışma kriterlerine uyan 40 hasta kontrol grubu olarak oluşturuldu.

Bulgular: Tekrarlayan gebelik kaybı olan grupta ortalama bazal follikül sayısı 9,4 (2,7) adet, kontrol grubunda 8,9 (2,5) adet olarak ölçüldü. (P=0,092). Tekrarlayan gebelik kaybı olan grupta ortalama AMH değeri 3,50 (1.92) ng/mL, kontrol grubunda 3,66 (2,14) ng/mL, (P=0,718), FSH değeri tekrarlayan düşük yapan grupta 6,77 (1,87) mIU/mL, kontrol grubunda 7,01 (1,29) mIU/mL (P=0,494), LH değeri sırasıyla 5,6 (1,8) mIU/mL ve 4,9 (1,7) mIU/mL, E2 değeri sırasıyla 87,7 (83,9) pg/mL, 48,4 (27,9) pg/mL olarak ölçüldü.

Sonuç: Over rezevr testlerinden tekrarlayan gebelik kaybı olan grup ile kontrol grubu arasında AMH, FSH değerleri arasında fark bulunmazken, tekrarlayan gebelik kaybı olan grupta estradiol seviyesi daha yüksek, bazal follikül sayısı ise daha düşük bulundu.

Aim: Approximately 1-2% of reproductive women have faced recurrent pregnancy loss (RPL). Ovarian reserve testing in the prediction of recurrent pregnancy loss is not usually performed. In this study, we aim to evaluate whether there were any differences between patients with and without a history of recurrent pregnancy loss (RPL) with regards to anti-Mullerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (Lh), estradiol (E2) levels and basal follicle count.

Methods: This case-control study was conducted between 1 January 2013 and 1 January 2015 in the Gynecology and Obstetrics Clinic of Adana Numune Training and Research Hospital. A total of 370 patients aged 17-37 years with a diagnosis of RPL during that 2-year period were contacted by telephone. Further evaluation was made of 40 patients who met the study criteria and gave verbal consent. Patients were called to the Gynecology Polyclinic for assessment on the 3rd day of their menstrual cycle, and a control group was formed of 40 patients with similar demographic characteristics who were referred to the Gynecology Polyclinic and met the study criteria. 

Results: The mean basal follicle count was determined as 9.4 (2.7) in the study group and 8.9 (2.5) in the control group (P=0.092). The mean AMH values in the RPL and control groups were 3.50 (1.92) ng/mL and 3.66 (2.14) ng/mL, respectively (P=0.718). The mean FSH values in the RPL and control groups were 6.77 (1.87) mIU/mL and 7.01 (1.90) mIU/mL, respectively (P=0.494). Mean LH values were measured as 5.6 (1.8) mIU/mL in the study group and 4.9 (1.7) mIU/mL in the control group. Mean E2 values were 87.7 (83.9) pg/mL and 48.4 (27.9) pg/mL in the study and control groups, respectively.

Conclusion: While no difference was found between the RPL and control groups in respect of AMH and FSH values in the ovarian reserve tests, the basal follicle count of the patients with recurrent pregnancy loss was found lower than that of the control group.

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Primary Language en
Subjects Obstetrics and Gynecology
Journal Section Research article
Authors

Orcid: 0000-0001-8465-3225
Author: Sadik KÜKRER (Primary Author)
Institution: University of Health Sciences, Adana City Training and Research Hospital, Adana, Turkey
Country: Turkey


Orcid: 0000-0002-0019-8403
Author: Sefa ARLIER
Institution: University of Health Sciences, Adana City Training and Research Hospital, Adana, Turkey
Country: Turkey


Orcid: 0000-0002-5768-8470
Author: Seyfettin Senih KARAMAN
Institution: University of Health Sciences, Adana City Training and Research Hospital, Adana, Turkey
Country: Turkey


Thanks The authors thank Ümit Ali Kayışlı for his contribution to this research
Dates

Publication Date : January 2, 2020

Bibtex @research article { josam670091, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {25 - 28}, doi = {10.28982/josam.670091}, title = {Ovarian reserve testing in the prediction of recurrent pregnancy loss}, key = {cite}, author = {Kükrer, Sadik and Arlıer, Sefa and Karaman, Seyfettin} }
APA Kükrer, S , Arlıer, S , Karaman, S . (2020). Ovarian reserve testing in the prediction of recurrent pregnancy loss . Journal of Surgery and Medicine , 4 (1) , 25-28 . DOI: 10.28982/josam.670091
MLA Kükrer, S , Arlıer, S , Karaman, S . "Ovarian reserve testing in the prediction of recurrent pregnancy loss" . Journal of Surgery and Medicine 4 (2020 ): 25-28 <http://jsurgmed.com/en/pub/issue/51597/670091>
Chicago Kükrer, S , Arlıer, S , Karaman, S . "Ovarian reserve testing in the prediction of recurrent pregnancy loss". Journal of Surgery and Medicine 4 (2020 ): 25-28
RIS TY - JOUR T1 - Ovarian reserve testing in the prediction of recurrent pregnancy loss AU - Sadik Kükrer , Sefa Arlıer , Seyfettin Karaman Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.670091 DO - 10.28982/josam.670091 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 25 EP - 28 VL - 4 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.670091 UR - https://doi.org/10.28982/josam.670091 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Ovarian reserve testing in the prediction of recurrent pregnancy loss %A Sadik Kükrer , Sefa Arlıer , Seyfettin Karaman %T Ovarian reserve testing in the prediction of recurrent pregnancy loss %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 1 %R doi: 10.28982/josam.670091 %U 10.28982/josam.670091
ISNAD Kükrer, Sadik , Arlıer, Sefa , Karaman, Seyfettin . "Ovarian reserve testing in the prediction of recurrent pregnancy loss". Journal of Surgery and Medicine 4 / 1 (January 2020): 25-28 . https://doi.org/10.28982/josam.670091
AMA Kükrer S , Arlıer S , Karaman S . Ovarian reserve testing in the prediction of recurrent pregnancy loss. J Surg Med. 2020; 4(1): 25-28.
Vancouver Kükrer S , Arlıer S , Karaman S . Ovarian reserve testing in the prediction of recurrent pregnancy loss. Journal of Surgery and Medicine. 2020; 4(1): 25-28.