Serum galectin-3 levels and vitamin D relationship in heart failure

Authors

Keywords:

Galectin 3, Congestive heart failure, Vitamin D3 level

Abstract

Background/Aim: Heart failure is an important health problem with an increasing incidence in the world and poor prognosis. Galectin-3 is associated with progressive fibrosis, an underlying pathology of heart failure, just as vitamin D deficiency. We examined the relationship between the stage of heart failure and galectin-3 and 25-OH vitamin D levels. Methods: Sixty patients with heart failure and 30 healthy volunteers were included in this prospective case-control study. Demographic data, comorbid diseases and laboratory data were examined, and 25-OH vitamin D and galectin-3 levels were compared between the patients with CHF and the control group. Results: Galectin-3 levels were high in patients with heart failure (P<0.001) and increased as the ejection fraction (EF) decreased (P=0.001). 25-OH vitamin D levels were lower in the patient group compared to the control group (P<0.001). There was no significant correlation between serum galectin-3 and vitamin D levels (r=-0.22; P=0.094); however, serum galectin-3 levels and the stage of CHF were correlated (r=0.66; P=0.001). Conclusions: We found high serum galectin-3 levels in patients with heart failure and low 25 OH vitamin D levels. We think that both molecules are important prognostic biomarkers in cardiac inflammation and fibrosis.

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References

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Published

2021-10-01

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Research Article

How to Cite

1.
Özcan M, Akarsu M, Aydın Yoldemir Şengül, Altun Özgür, Kutlu O, Kalyon S, Yürüyen G, Özkan Gümüşkaya P, Özsoy N, Eruzun H, Arman Y, Tükek T. Serum galectin-3 levels and vitamin D relationship in heart failure. J Surg Med [Internet]. 2021 Oct. 1 [cited 2024 Mar. 28];5(10):1046-9. Available from: https://jsurgmed.com/article/view/1003992