The relationship between zinc and hepatic steatosis

Authors

Keywords:

Zinc, Trace element, Hepatic steatosis

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most commonly diagnosed liver disease in the recent years, with a prevalence of 15-20% among normal population. Liver steatosis is also a complication of obesity and affects 22-52% of obese children. In this aspect, it is an important public health problem. Increases in the amount of fatty acids entering the liver, increase in fatty acid synthesis and disorders in its secretion are included in its pathogenesis. The relationship between zinc, which is the second most abundant trace element found in the body after iron and necessary for many enzymes to function properly, and fatty liver disease has been shown in previous studies. The aim of this review is to discuss the relationship between zinc and liver steatosis in the light of current studies and contribute to the literature.

Downloads

Download data is not yet available.

References

Cairns SR, Peters TJ. Biochemical analysis of hepatic lipid in alcoholic and diabetic and control subjects. Clin Sci. 1983;65:645–52.

Burdette HL, Whitaker RC, Kahn RS. Association of maternal obesity and depressive symptoms with television-viewing time in low-income preschool children. Arch Pediatr Adolesc Med. 2003;157:894-9.

Day CP, James OF. Steatohepatitis: a tale of two “hits”?, Gastroenterology. 1998;114:842-5.

Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006;43:99-112.

Sentürk Ö. Nonalkolik Yaglı Karaciger Hastalıgı (NAYKH). Folia. 2004;1:12-7.

Wessels I, Maywald M, Rink L. Zinc as a gatekeeper of immune function. Nutrients. 2017;9:1286.

Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev. 1993;73:79–118.

Powell SR. The antioxidant properties of zinc. J Nutr. 2000;130:1447–54.

Leoni G, Rosato A, Perozzi G. Zinc proteome interaction network as a model to identify nutrient-affected pathways in human pathologies. Genes Nutr. 2014;9:436.

Roohani N, Hurrell R, Kelishadi R, Schulin R. Zinc and its importance for human health: Anintegrative review. J Res Med Sci. 2013;18(2):144-57.

Mohammad KM, Zhou Z, Cave M, Barve A, Mc Clain CJ. Zinc and Liver Disease. Nutr Clin Pract. 2012;27(1):8-20.

Shidfar F, Faghihi A, Amiri HL, Mousavi SN. Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats. Iran J Med Sci. 2018;43:26-31.

Elias I, Franckhauser S, Ferre T, Vila L,Tafuro S, Munoz S, et al. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes. 2012;61:1801-13.

Stamoulis I, Kouraklis G, Theocharis S. Zinc and the liver: an active interaction. Dig Dis Sci. 2007;52:1595-612.

Kadhim HM, Ismail SH, Hussein KI, Bakir IH, Sahib AS, Khalaf BH, et al. Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin. J Pineal Res. 2006;41:189-93.

Gaetke LM, Mc Clain CJ, Talwalkar RT, Shedlofsky SI. Effects of endotoxin on zinc metabolism in human volunteers. Am J Physiol. 1997;272:E952-6.

Tarantino G, Savastano S, Colao A. Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance. World J Gastroenterol. 2010;16:4773–83.

Afridi HI, Kazi TG, Kazi N, Baig JA, Jamali MK, Arain MB, et al. Status of essential trace metals in biological samples of diabetic mother and their neonates. Arch Gynecol Obstet. 2009;280:415–23.

Viktorínová A, Tošerová E, Križko M, Ďuračková Z. Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus. Metabolism. 2009;58:1477–82.

Farvid MS, Siassi F, Jalali M, Hosseini M, Saadat N. The impact of vitamin and/or mineral supplementation on lipid profiles in type 2 diabetes. Diabetes Res Clin Pract. 2004;65:21–8.

Kelishadi R, Hashemipour M, Adeli K, Tavakoli N, Movahedian- Attar A, Shapouri J, et al. Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome. Metab Syndr Relat Disord. 2010;8:505–10.

Nascimento Marreiro D, Fisberg M, Cozzolino SMF. Zinc nutritional status and its relationships with hyperinsulinemia in obese children and adolescents. Biol Trace Elem Res. 2004;100:137–49.

Tungtrongchitr R, Pongpaew P, Phonrat B, Tungtrongchitr A, Viroonudomphol D, Vudhivai N, et al. Serum copper, zinc, ceruloplasmin and superoxide dismutase in Thai overweight and obese. J Med Assoc Thai. 2003;86:543–51.

Rossner S. Childhood obesity and adulthood consequences. Acta Paediatr. 1998;87:1-5.

Martorell R, Kettle K, Hughes ML, Grummer-Stawn ML. Overweight and obesity in preschool children from developing countries. Int J Obes Relat Metab Disord. 2000;24:959-67.

Mousavi SN, Faghihi A, Motaghinejad M, Shiasi M, Imanparast F, Amiri HL, et al. Zinc and Selenium Co-supplementation Reduces Some Lipid Peroxidation and Angiogenesis Markers in a Rat Model of NAFLD-Fed High Fat Diet. Biol Trace Elem Res. 2018;181(2):288-95.

Adams LA, Angulo P, Lindor KD. Nonalcoholic fatty liver disease. Can Med Assoc J. 2005;172:899–905.

Uchiyama S, Shimizu T, Shirasawa T. Cu Zn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice. J Biol Chem. 2006;281:31713–9.

Shaheen AA, el-Fattah AA. Effect of dietary zinc on lipid peroxidation, glutathione, protein thiols levels and superoxide dismutase activity in rat tissues. Int J Biochem Cell Biol. 1995;27:89–95.

Ozturk A, Baltaci AK, Mogulkoc R, Oztekin E, Sivrikaya A, Kurtoglu E, et al. Effects of zinc deficiency and supplementation on malondialdehyde and glutathione levels in blood and tissues of rat performing swimming exercise. Biol Trace Elem. 2003;94:157–66.

Himoto T, Nomura T, Tani J, Miyoshi H, Morishita A, Yoneyama H, et al. Exacerbation of Insulin Resistance and Hepatic Steatosis Deriving from Zinc Deficiency in Patients with HCV-Related Chronic Liver Disease. Biol Trace Elem Res. 2015;163:81–8.

Mikhail TH, Nicola WG, Ibrahim KH, Salama SH, Emam M. Abnormal zinc and copper metabolism in hepatic steatosis. Boll Chim Farmaceuticol. 1996;135:591–7.

Bode JC, Hanisch P, Henning H, Koenig W, Richter FW, Bode C. Hepatic zinc content in patients with various stages of alcoholic liver disease and in patients with chronic active and chronic persistent hepatitis. Hepatology. 1988;6:1605–9.

Gimenez A, Pares A, Alie S, Camps J, Deulofeu R, Caballeria J, et al. Fibrogenetic and collagenolytic activity in carbontetrachloride-injured rats: beneficial effects of zinc administration. J Hepatol. 1994;21:292–8.

Baltaci AK, Mogulkoc R, Salbacak A, Celik I, Sivrikaya A. The role of zinc supplementation in the inhibition of tissue damage caused by exposure to electoromagnetic field in rat lung and liver tissues. Bratisl Lek Listy. 2012;113:400–3.

Downloads

Published

2019-08-01

Issue

Section

Review

How to Cite

1.
Dikker O, Dağ H, Türkkan E, Çetin Dağ N, Çakar NE. The relationship between zinc and hepatic steatosis. J Surg Med [Internet]. 2019 Aug. 1 [cited 2024 Apr. 25];3(8):609-11. Available from: https://jsurgmed.com/article/view/608618