Case Report
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Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report

Year 2021, Volume 5, Issue 9, 992 - 994, 01.09.2021
https://doi.org/10.28982/josam.858692

Abstract

Corneal and conjunctival intraepithelial neoplasia is a slowly progressive ocular surface lesion with low malignant potential. Owing to the high recurrence rates, cryotherapy or topical chemotherapy is used with surgical treatment. In this paper, we report the histopathologic findings and treatment of a case of intraepithelial neoplasia that began in the conjunctiva and progressed to the cornea. A 75-year-old woman presented with complaints of redness, irritation and lacrimation in her left eye for around 1 month. Slit-lamp examination revealed a papilliform mass on the nasal conjunctiva along with involvement of the adjacent corneal epithelium. Conjunctival excisional biopsy showed a moderate epithelial dysplasia. Topical 0.04% mitomycin C was administered 4 times daily for 3 weeks. No recurrence was observed in the following 18 months.

References

  • 1. Kao AA, Galor A, Karp CL, Abdelaziz A, Feuer WJ, Dubovy SR. Clinicopathologic correlation of ocular surface squamous neoplasms at Bascom Palmer Eye Institute: 2001 to 2010. Ophthalmology. 2012;119(9):1773-6. doi: 10.1016/j.ophtha.2012.02.049.
  • 2. Gichuhi S, Ohnuma S, Sagoo MS, Burton MJ. Pathophysiology of ocular surface squamous neoplasia. Exp Eye Res. 2014;129:172-82. doi: 10.1016/j.exer.2014.10.015.
  • 3. Hamam R, Bhat P, Foster CS. Conjunctival/corneal intraepithelial neoplasia. Int Ophthalmol Clin. 2009;49(1):63-70. doi: 10.1097/IIO.0b013e3181924ec3.
  • 4. Scholz SL, Thomasen H, Reis H, Möller I, Darawsha R, Müller B, et al. Frequent TERT promoter mutations in ocular surface squamous neoplasia. Invest Ophthalmol Vis Sci. 2015;56(10):5854-61. doi: 10.1167/iovs.15-17469.
  • 5. Pe'er J. Ocular surface squamous neoplasia: evidence for topical chemotherapy. Int Ophthalmol Clin. 2015;55(1):9-21. doi: 10.1097/IIO.0000000000000050.
  • 6. Frucht-Pery J, Rozenman Y, Pe'er J. Topical mitomycin-C for partially excised conjunctival squamous cell carcinoma. Ophthalmology. 2002;109(3):548-52. doi: 10.1016/s0161-6420(01)00967-8.
  • 7. Giaconi JA, Karp CL. Current treatment options for conjunctival and corneal intraepithelial neoplasia. Ocul Surf. 2003;1:66-73.
  • 8. Galor A, Karp CL, Oellers P, Kao AA, Abdelaziz A, Feuer W, et al. Predictors of ocular surface squamous neoplasia recurrence after excisional surgery. Ophthalmology. 2012;119(10):1974-81. doi: 10.1016/j.ophtha.2012.04.022.
  • 9. Tabin G, Levin S, Snibson G, Loughnan M, Taylor H. Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology. 1997;104(3):485-92. doi: 10.1016/s0161-6420(97)30287-5.
  • 10. Besley J, Pappalardo J, Lee GA, Hirst LW, Vincent SJ. Risk factors for ocular surface squamous neoplasia recurrence after treatment with topical mitomycin C and interferon alpha-2b. Am J Ophthalmol. 2014;157(2):287-93. doi: 10.1016/j.ajo.2013.10.012.
  • 11. McKelvie PA, Daniell M. Impression cytology following mitomycin C therapy for ocular surface squamous neoplasia. Br J Ophthalmol. 2001;85(9):1115-9. doi: 10.1136/bjo.85.9.1115.
  • 12. Frucht-Pery J, Rozenman Y. Mitomycin C therapy for corneal intraepithelial neoplasia. Am J Ophthalmol. 1994;117(2):164-8. doi: 10.1016/s0002-9394(14)73072-7.
  • 13. Soysal HG, Yazar Z. The efficacy of postoperative topical mitomycin C in the treatment of conjunctival epithelial neoplasia. Turk J Ophthalmol. 2008;38(6):464-7.
  • 14. Khong JJ, Muecke J. Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia. Br J Ophthalmol. 2006;90(7):819-22. doi: 10.1136/bjo.2005.086850.
  • 15. Dudney BW, Malecha MA. Limbal stem cell deficiency following topical mitomycin C treatment of conjunctival-corneal intraepithelial neoplasia. Am J Ophthalmol. 2004;137(5):950-1. doi: 10.1016/j.ajo.2003.10.048.

Korneal ve konjonktival intraepitelyal neoplazide topikal mitomisin C tedavisi: olgu sunumu

Year 2021, Volume 5, Issue 9, 992 - 994, 01.09.2021
https://doi.org/10.28982/josam.858692

Abstract

Korneal ve konjonktival intraepitelyal neplazi, düşük malignite potansiyeli olan yavaş ilerleyen bir oküler yüzey lezyonudur. Yüksek nüks oranları nedeniyle kriyoterapi veya topikal kemoterapi cerrahi tedavi ile birlikte kullanılmaktadır. Çalışmamızda, konjonktivada başlayıp korneaya ilerleyen intraepitelyal neoplazili olgunun histopatolojik bulgularını ve tedavisini sunduk. Yetmiş beş yaşında kadın hasta yaklaşık 1 aydır devam eden sol gözünde kızarıklık, batma ve sulanma şikayetleri ile kliniğe başvurdu. Biyomikroskobik muayenede; nazal konjonktivada papilliform kitle ve bitişik kornea epitelinde tutulum mevcuttu. Konjonktival eksizyonel biyopsi sonucu orta derecede epitelyal displazi olarak raporlandı. Hastaya günde 4 defa, 3 hafta süresince topikal %0,04 mitomisin C uygulandı. Takip eden 18 aylık sürede nüks gelişmedi.

References

  • 1. Kao AA, Galor A, Karp CL, Abdelaziz A, Feuer WJ, Dubovy SR. Clinicopathologic correlation of ocular surface squamous neoplasms at Bascom Palmer Eye Institute: 2001 to 2010. Ophthalmology. 2012;119(9):1773-6. doi: 10.1016/j.ophtha.2012.02.049.
  • 2. Gichuhi S, Ohnuma S, Sagoo MS, Burton MJ. Pathophysiology of ocular surface squamous neoplasia. Exp Eye Res. 2014;129:172-82. doi: 10.1016/j.exer.2014.10.015.
  • 3. Hamam R, Bhat P, Foster CS. Conjunctival/corneal intraepithelial neoplasia. Int Ophthalmol Clin. 2009;49(1):63-70. doi: 10.1097/IIO.0b013e3181924ec3.
  • 4. Scholz SL, Thomasen H, Reis H, Möller I, Darawsha R, Müller B, et al. Frequent TERT promoter mutations in ocular surface squamous neoplasia. Invest Ophthalmol Vis Sci. 2015;56(10):5854-61. doi: 10.1167/iovs.15-17469.
  • 5. Pe'er J. Ocular surface squamous neoplasia: evidence for topical chemotherapy. Int Ophthalmol Clin. 2015;55(1):9-21. doi: 10.1097/IIO.0000000000000050.
  • 6. Frucht-Pery J, Rozenman Y, Pe'er J. Topical mitomycin-C for partially excised conjunctival squamous cell carcinoma. Ophthalmology. 2002;109(3):548-52. doi: 10.1016/s0161-6420(01)00967-8.
  • 7. Giaconi JA, Karp CL. Current treatment options for conjunctival and corneal intraepithelial neoplasia. Ocul Surf. 2003;1:66-73.
  • 8. Galor A, Karp CL, Oellers P, Kao AA, Abdelaziz A, Feuer W, et al. Predictors of ocular surface squamous neoplasia recurrence after excisional surgery. Ophthalmology. 2012;119(10):1974-81. doi: 10.1016/j.ophtha.2012.04.022.
  • 9. Tabin G, Levin S, Snibson G, Loughnan M, Taylor H. Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology. 1997;104(3):485-92. doi: 10.1016/s0161-6420(97)30287-5.
  • 10. Besley J, Pappalardo J, Lee GA, Hirst LW, Vincent SJ. Risk factors for ocular surface squamous neoplasia recurrence after treatment with topical mitomycin C and interferon alpha-2b. Am J Ophthalmol. 2014;157(2):287-93. doi: 10.1016/j.ajo.2013.10.012.
  • 11. McKelvie PA, Daniell M. Impression cytology following mitomycin C therapy for ocular surface squamous neoplasia. Br J Ophthalmol. 2001;85(9):1115-9. doi: 10.1136/bjo.85.9.1115.
  • 12. Frucht-Pery J, Rozenman Y. Mitomycin C therapy for corneal intraepithelial neoplasia. Am J Ophthalmol. 1994;117(2):164-8. doi: 10.1016/s0002-9394(14)73072-7.
  • 13. Soysal HG, Yazar Z. The efficacy of postoperative topical mitomycin C in the treatment of conjunctival epithelial neoplasia. Turk J Ophthalmol. 2008;38(6):464-7.
  • 14. Khong JJ, Muecke J. Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia. Br J Ophthalmol. 2006;90(7):819-22. doi: 10.1136/bjo.2005.086850.
  • 15. Dudney BW, Malecha MA. Limbal stem cell deficiency following topical mitomycin C treatment of conjunctival-corneal intraepithelial neoplasia. Am J Ophthalmol. 2004;137(5):950-1. doi: 10.1016/j.ajo.2003.10.048.

Details

Primary Language English
Subjects Ophthalmology
Journal Section Case report
Authors

Asena KELEŞ ŞAHİN (Primary Author)
ORDU ÜNİVERSİTESİ
0000-0002-2700-0866
Türkiye


Aslıhan UZUN
ORDU ÜNİVERSİTESİ
0000-0002-5787-3879
Türkiye


Havva ERDEM
ORDU ÜNİVERSİTESİ
0000-0002-3074-0240
Türkiye

Supporting Institution Yazarlar tarafından bu çalışma için finansal destek alınmamıştır
Publication Date September 1, 2021
Published in Issue Year 2021, Volume 5, Issue 9

Cite

Bibtex @case report { josam858692, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2021}, volume = {5}, pages = {992 - 994}, doi = {10.28982/josam.858692}, title = {Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report}, key = {cite}, author = {Keleş Şahin, Asena and Uzun, Aslıhan and Erdem, Havva} }
APA Keleş Şahin, A. , Uzun, A. & Erdem, H. (2021). Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report . Journal of Surgery and Medicine , 5 (9) , 992-994 . DOI: 10.28982/josam.858692
MLA Keleş Şahin, A. , Uzun, A. , Erdem, H. "Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report" . Journal of Surgery and Medicine 5 (2021 ): 992-994 <http://jsurgmed.com/en/pub/issue/64812/858692>
Chicago Keleş Şahin, A. , Uzun, A. , Erdem, H. "Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report". Journal of Surgery and Medicine 5 (2021 ): 992-994
RIS TY - JOUR T1 - Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report AU - Asena Keleş Şahin , Aslıhan Uzun , Havva Erdem Y1 - 2021 PY - 2021 N1 - doi: 10.28982/josam.858692 DO - 10.28982/josam.858692 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 992 EP - 994 VL - 5 IS - 9 SN - -2602-2079 M3 - doi: 10.28982/josam.858692 UR - https://doi.org/10.28982/josam.858692 Y2 - 2021 ER -
EndNote %0 Journal of Surgery and Medicine Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report %A Asena Keleş Şahin , Aslıhan Uzun , Havva Erdem %T Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report %D 2021 %J Journal of Surgery and Medicine %P -2602-2079 %V 5 %N 9 %R doi: 10.28982/josam.858692 %U 10.28982/josam.858692
ISNAD Keleş Şahin, Asena , Uzun, Aslıhan , Erdem, Havva . "Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report". Journal of Surgery and Medicine 5 / 9 (September 2021): 992-994 . https://doi.org/10.28982/josam.858692
AMA Keleş Şahin A. , Uzun A. , Erdem H. Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report. J Surg Med. 2021; 5(9): 992-994.
Vancouver Keleş Şahin A. , Uzun A. , Erdem H. Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report. Journal of Surgery and Medicine. 2021; 5(9): 992-994.
IEEE A. Keleş Şahin , A. Uzun and H. Erdem , "Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report", Journal of Surgery and Medicine, vol. 5, no. 9, pp. 992-994, Sep. 2021, doi:10.28982/josam.858692

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