Year 2020, Volume 4 , Issue 9, Pages 738 - 742 2020-09-01

Hiperkalorik enteral müdahalenin altı yaşından önce ateşli nöbet geçmişi olan malnütrisyon hastalarına etkileri
Effects of hypercaloric enteral intervention on malnutrition patients with a history of febrile seizure before the age of six

Eda SÜNNETÇİ SİLİSTRE [1] , Özlem ÖZPENPE [2] , Halil Uğur HATİPOĞLU [3] , Ali DOĞAN [4] , Fatih OZDENER [5]


Amaç: Ateşli nöbet en yaygın olarak 3 ila 60 aylık çocuklarda görülen (~% 5) ve demir eksikliği ile ilişkilendirilen bir konvülsiyondur. Bu nedenle, yetersiz beslenme ateşli nöbetin olumsuz sonuçlarını artırabilir. Bu çalışmada, 6 yaşından önce ateşli konvülsiyon öyküsü olan yetersiz beslenen çocuklarda hiperkalorik (1,5 kcal/mL) beslenme müdahalesinin etkilerini sunulmaktadır. Yöntemler: Çalışma kohortu ateşli nöbet öyküsü olan 1-6 yaş arası 44 hastadan oluşmakta olup, tüm hastalara hiperkalorik beslenme müdahalesi uygulanmıştır. Hastaların ilk başvuruları sırasında kaydedilen antropometrik değerler ve mikronütrient ölçümleri, 3. ay ve 6. ay vizitleri ile karşılaştırılmıştır. Tüm hasta kayıtları, İstanbul, Türkiye İstanbul Eğitim ve Araştırma Hastanesi'nden geriye dönük olarak alınmıştır. Bulgular: Müdahale sonrasında ağırlık (P=0,002) ve vücut kitle indeksi (P<0,001) z-skorlarında anlamlı iyileşmeler görülmüştür. Demir ve 25-hidroksivitamin D3 (25D3) eksikliği olan hastaların yaklaşık% 50'si düzelme gösterirken serum konsantrasyonlarında da önemli ölçüde artış gözlemlenmiştir (her ikisi için de P<0,001). Tedavi, demir eksikliği olmayan hastalarda demir konsantrasyonlarını etkilememiştir (P=0,074). 25D3, folat ve vitamin B12 konsantrasyonları normal olan hastalarda, bu mikronütrientler herhangi bir toksisiteye neden olmaksızın optimal aralıklar içinde kalmıştır. Sonuçlar: Hiperkalorik beslenme müdahalesi herhangi bir toksisiteye neden olmaksızın ateşli nöbet öyküsü olan 6 yaşın altındaki malnütrisyon teşhisi konulan pediatrik hastalarda demir ve 25D3 eksikliğini azaltmıştır ve vücut kitle indeksi ile ağırlık z-skorlarını anlamlı ölçüde düzeltmiştir.
Aim: Febrile seizure is the most prevalent (~5%) convulsion in children between 3 to 60 months of age and has been related to iron deficiency. Thus, when it is combined with malnutrition, it may increase negative outcomes. In this study, we present the effects of hypercaloric (1.5 kcal mL-1) nutritional intervention on undernourished children with a history of febrile convulsions prior to the age of 6. Methods: A cohort of 44 patients between ages 1-6 years with a history of a febrile seizure was included in the study. Hypercaloric nutritional intervention was applied to all patients. Baseline patient records containing anthropometrical and micronutrient measurements were compared with the 3rd month and the 6th month visits. All patient records were retrospectively obtained from Istanbul Research and Training Hospital, İstanbul, Turkey. Results: There were significant improvements in the z-scores of weight (P=0.002) and body mass index (P<0.001). Approximately 50% of iron and 25-hydroxyvitamin D3 (25D3) deficient patients were cured and their serum concentrations increased significantly (P<0.001 for both). Treatment did not affect iron concentrations in patients without iron deficiency (P=0.074). Normal concentrations of 25D3, folate, and vitamin B12 improved inside the optimal micronutrient ranges without toxicity. Conclusion: Overall, hypercaloric nutritional intervention abated iron and 25D3 deficiency and significantly improved the z-scores of BMI and weight in malnourished pediatric patients under the age of 6 with a history of febrile seizures without toxicity.
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Primary Language en
Subjects Clinical Neurology, Pediatrics
Journal Section Research article
Authors

Orcid: 0000-0003-0450-0152
Author: Eda SÜNNETÇİ SİLİSTRE (Primary Author)
Institution: Istanbul Research and Training Hospital, Department of Pediatric Health and Diseases
Country: Turkey


Orcid: 0000-0002-6137-5936
Author: Özlem ÖZPENPE
Institution: Istanbul Research and Training Hospital, Department of Pediatric Health and Diseases
Country: Turkey


Orcid: 0000-0002-7393-677X
Author: Halil Uğur HATİPOĞLU
Institution: Istanbul Research and Training Hospital, Department of Pediatric Health and Diseases
Country: Turkey


Orcid: 0000-0002-9040-2737
Author: Ali DOĞAN
Institution: Nutricia, Advanced Medical Nutrition, Medical Department
Country: Turkey


Orcid: 0000-0002-0163-318X
Author: Fatih OZDENER
Institution: Bahcesehir University, School of Medicine, Department of Pharmacology
Country: Turkey


Dates

Publication Date : September 1, 2020

Bibtex @research article { josam788917, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {738 - 742}, doi = {10.28982/josam.788917}, title = {Effects of hypercaloric enteral intervention on malnutrition patients with a history of febrile seizure before the age of six}, key = {cite}, author = {Sünnetçi̇ Si̇li̇stre, Eda and Özpenpe, Özlem and Hati̇poğlu, Halil Uğur and Doğan, Ali and Ozdener, Fatih} }
APA Sünnetçi̇ Si̇li̇stre, E , Özpenpe, Ö , Hati̇poğlu, H , Doğan, A , Ozdener, F . (2020). Effects of hypercaloric enteral intervention on malnutrition patients with a history of febrile seizure before the age of six . Journal of Surgery and Medicine , 4 (9) , 738-742 . DOI: 10.28982/josam.788917
MLA Sünnetçi̇ Si̇li̇stre, E , Özpenpe, Ö , Hati̇poğlu, H , Doğan, A , Ozdener, F . "Effects of hypercaloric enteral intervention on malnutrition patients with a history of febrile seizure before the age of six" . Journal of Surgery and Medicine 4 (2020 ): 738-742 <http://jsurgmed.com/en/pub/issue/56766/788917>
Chicago Sünnetçi̇ Si̇li̇stre, E , Özpenpe, Ö , Hati̇poğlu, H , Doğan, A , Ozdener, F . "Effects of hypercaloric enteral intervention on malnutrition patients with a history of febrile seizure before the age of six". Journal of Surgery and Medicine 4 (2020 ): 738-742
RIS TY - JOUR T1 - Effects of hypercaloric enteral intervention on malnutrition patients with a history of febrile seizure before the age of six AU - Eda Sünnetçi̇ Si̇li̇stre , Özlem Özpenpe , Halil Uğur Hati̇poğlu , Ali Doğan , Fatih Ozdener Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.788917 DO - 10.28982/josam.788917 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 738 EP - 742 VL - 4 IS - 9 SN - -2602-2079 M3 - doi: 10.28982/josam.788917 UR - https://doi.org/10.28982/josam.788917 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Effects of hypercaloric enteral intervention on malnutrition patients with a history of febrile seizure before the age of six %A Eda Sünnetçi̇ Si̇li̇stre , Özlem Özpenpe , Halil Uğur Hati̇poğlu , Ali Doğan , Fatih Ozdener %T Effects of hypercaloric enteral intervention on malnutrition patients with a history of febrile seizure before the age of six %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 9 %R doi: 10.28982/josam.788917 %U 10.28982/josam.788917
ISNAD Sünnetçi̇ Si̇li̇stre, Eda , Özpenpe, Özlem , Hati̇poğlu, Halil Uğur , Doğan, Ali , Ozdener, Fatih . "Effects of hypercaloric enteral intervention on malnutrition patients with a history of febrile seizure before the age of six". Journal of Surgery and Medicine 4 / 9 (September 2020): 738-742 . https://doi.org/10.28982/josam.788917
AMA Sünnetçi̇ Si̇li̇stre E , Özpenpe Ö , Hati̇poğlu H , Doğan A , Ozdener F . Effects of hypercaloric enteral intervention on malnutrition patients with a history of febrile seizure before the age of six. J Surg Med. 2020; 4(9): 738-742.
Vancouver Sünnetçi̇ Si̇li̇stre E , Özpenpe Ö , Hati̇poğlu H , Doğan A , Ozdener F . Effects of hypercaloric enteral intervention on malnutrition patients with a history of febrile seizure before the age of six. Journal of Surgery and Medicine. 2020; 4(9): 738-742.