Relationship between atherosclerosis risks and lipoprotein-dependent phospholipase a2 activity in type 2 diabetic patients

Durmuş Ayan; Ayşe Banu Çaycı Sivri; Seher Yüksel; İlhan Yetkin; Hakan Özdemir

doi:10.28982/josam.440016

Authors

Durmuş Ayan
Ayşe Banu Çaycı Sivri
Seher Yüksel
İlhan Yetkin
Hakan Özdemir

DOI:

https://doi.org/10.28982/josam.440016

Keywords:

Lp-PLA2, Atherosclerosis, Diabetes, Statin therapy, Intima-media thickness

Abstract

Aim: Atherosclerosis is the most common macro-complication of diabetes and the most common cause of coronary artery disease. We aimed to investigate the relationship between the risk of atherosclerosis and lipoprotein-dependent phospholipase A2 activity in patients with type 2 diabetes.

Methods: The study was enrolled on 48 subjects: Group I: control group consisting of 20 healthy participants. Group II: 28 patients of type 2 diabetes mellitus before statin (rosuvastatin 10 mg/day) therapy. Group III: 28 patients of type 2 diabetes mellitus after statin (rosuvastatin 10 mg/day) therapy. Lp-PLA2 activity was measured with immuno- turbidimetric method (plac test kit), HDL-C (High-Density Lipoprotein Cholesterol), LDL-C (Low-Density Lipoprotein Cholesterol), triglyceride, cholesterol and fasting blood glucose (FBG), levels were measured by spectrophotometric method using autoanalyzer (Architect C16000). LDL-C levels were measured by an assay for the direct quantification of LDL-C. Carotid intima-media thickness (IMT) was measured by B-mode ultrasonography method.

Results: Serum Lp-PLA2 activity, serum LDL-C, triglyceride, cholesterol levels and IMT values of Group II (before 10 mg/gün rosuvastatin therapy ) and Group III (after rosuvastatin therapy) patients were statistically significant higher than Group I (control group) (p<0.01) Serum Lp-PLA2 activity, serum LDL-C, triglyceride, cholesterol levels and IMT values of Group II patients were statistically significant higher than Group III patients (p<0.01) and HDL-C levels only were lower than Group III (after 10 mg/gün rosuvastatin therapy) but It was not statistically significant (p=0.198).

Conclusion: According to our results, Increased Lp-PLA2 activity is associated with risk of atherosclerosis in diabetic patients and plays an important role in the progression of atherosclerosis.

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