Year 2020, Volume 4 , Issue 1, Pages 16 - 20 2020-01-02

The effect of dexpanthenol on the formation of epidural fibrosis in an experimental laminectomy model in rats
Deneysel epidural fibrosis modelinde dextpanthenol’ün epidural fibrosis oluşumu üzerine etkisi

Zahir KIZILAY [1] , Nesibe KAHRAMAN ÇETİN [2] , Soner YAYCIOĞLU [3] , Murat Özcan YAY [4] , Hakan ÖZTÜRK [5] , Çiğdem YENİSEY [6]


Aim: Epidural fibrosis, which develops after spinal surgery, is one of the factors which reduce the chances of successful surgery in the medium and long term by tightly surrounding the dura and spinal roots. In this experimental study, the aim was to compare the effects of local and systemic administration of dexpanthenol on epidural fibrosis formation in rats.

Methods: Twenty-eight rats were randomly divided into 4 equal groups (control, Spongostan, local dexpanthenol and systemic dexpanthenol) and laminectomy was performed at the T11 level. Local dexpanthenol (500mg/kg) was administered with Spongostan, and systemic dexpanthenol (500 mg/kg) was administered once a day for three weeks. Epidural fibrosis, arachnoidal involvement, fibroblast cell count, vascular endothelial growth factor, and hydroxyproline levels were evaluated. 

Results: The grade of epidural fibrosis, fibroblast cell counts, and hydroxyproline levels were significantly lower in the systemic dexpanthenol groups (P=0.025).

Conclusion: Dexpanthenol may be used as potential agent for reducing epidural fibrosis. However, it should be administered more than once for it to take effect.

Amaç: Spinal cerrahi sonrası gelişen epidural fibrosis dura ve spinal köklerin çevresini sıkıca sararak orta ve uzun vadede cerrahinin balşarı şansını azaltan nedenlerden biridir. Bu nedenle, bu deneysel çalışmada, ratlarda local ve sistemik dekspanthenol uygulamasının epidural fibrosis oluşumu üzerine etkisini karşılaştırmak amaç edinilmiştir.

Yöntemler: Yirmi sekiz adet sıçan rastlantısal olarak 4 eşit gruba ayrıldı (Kontrol, spongostan, local dekspanthenol ve sistemik dekspanthenol) ve bütün sıçanların torakal 11 düzeyine laminektomi yapıldı. Local olarak dexpanthenol 500 mg/kg dan spongostan ile uygulandı. Sistemik olarak dexpanthanol, 500 mg/kg dan günde bir defa olmak üzere 3 hafta boyunca uygulandı. Epidural fibrosis, araknoid tutulum, fibroblast hücre sayısı, vasküler endotelyal büyüme faktörü ve hidroksiprolini çeriği değerlendirildi.

Bulgular: Epidural fibrosis derecesi, fibroblast hücre sayısı ve hidroksiprolin düzeyi istatistiksel olarak anlamlı düzeyde sistemik dekspanthenol grubunda düşüktü (P=0,025).

Sonuç: Dekspanthenol epidural fibrosisi azaltmak için potansiyel bir ajan olabilir, fakat bu etkinin ortaya çıkması için birden fazla sayıda verilmesi gereklidir.

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Primary Language en
Subjects Medicine, Research and Experimental
Journal Section Research article
Authors

Orcid: 0000-0002-2021-0406
Author: Zahir KIZILAY (Primary Author)
Institution: ADNAN MENDERES UNIVERSITY, FACULTY OF MEDICINE
Country: Turkey


Orcid: 0000-0002-4549-1670
Author: Nesibe KAHRAMAN ÇETİN
Institution: ADNAN MENDERES UNIVERSITY, FACULTY OF MEDICINE
Country: Turkey


Orcid: 0000-0001-9230-1107
Author: Soner YAYCIOĞLU
Institution: ADNAN MENDERES UNIVERSITY, FACULTY OF MEDICINE
Country: Turkey


Orcid: 0000-0001-8990-7642
Author: Murat Özcan YAY
Institution: ADNAN MENDERES UNIVERSITY, FACULTY OF MEDICINE
Country: Turkey


Orcid: 0000-0001-8112-4934
Author: Hakan ÖZTÜRK
Institution: ADNAN MENDERES UNIVERSITY, FACULTY OF MEDICINE
Country: Turkey


Orcid: 0000-0001-7693-641X
Author: Çiğdem YENİSEY
Institution: ADNAN MENDERES UNIVERSITY, FACULTY OF MEDICINE
Country: Turkey


Supporting Institution none
Project Number none
Thanks none
Dates

Publication Date : January 2, 2020

Bibtex @research article { josam597612, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {16 - 20}, doi = {10.28982/josam.597612}, title = {The effect of dexpanthenol on the formation of epidural fibrosis in an experimental laminectomy model in rats}, key = {cite}, author = {KIZILAY, Zahir and KAHRAMAN ÇETİN, Nesibe and YAYCIOĞLU, Soner and YAY, Murat Özcan and ÖZTÜRK, Hakan and YENİSEY, Çiğdem} }
APA KIZILAY, Z , KAHRAMAN ÇETİN, N , YAYCIOĞLU, S , YAY, M , ÖZTÜRK, H , YENİSEY, Ç . (2020). The effect of dexpanthenol on the formation of epidural fibrosis in an experimental laminectomy model in rats. Journal of Surgery and Medicine , 4 (1) , 16-20 . DOI: 10.28982/josam.597612
MLA KIZILAY, Z , KAHRAMAN ÇETİN, N , YAYCIOĞLU, S , YAY, M , ÖZTÜRK, H , YENİSEY, Ç . "The effect of dexpanthenol on the formation of epidural fibrosis in an experimental laminectomy model in rats". Journal of Surgery and Medicine 4 (2020 ): 16-20 <http://jsurgmed.com/en/issue/51597/597612>
Chicago KIZILAY, Z , KAHRAMAN ÇETİN, N , YAYCIOĞLU, S , YAY, M , ÖZTÜRK, H , YENİSEY, Ç . "The effect of dexpanthenol on the formation of epidural fibrosis in an experimental laminectomy model in rats". Journal of Surgery and Medicine 4 (2020 ): 16-20
RIS TY - JOUR T1 - The effect of dexpanthenol on the formation of epidural fibrosis in an experimental laminectomy model in rats AU - Zahir KIZILAY , Nesibe KAHRAMAN ÇETİN , Soner YAYCIOĞLU , Murat Özcan YAY , Hakan ÖZTÜRK , Çiğdem YENİSEY Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.597612 DO - 10.28982/josam.597612 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 16 EP - 20 VL - 4 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.597612 UR - https://doi.org/10.28982/josam.597612 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine The effect of dexpanthenol on the formation of epidural fibrosis in an experimental laminectomy model in rats %A Zahir KIZILAY , Nesibe KAHRAMAN ÇETİN , Soner YAYCIOĞLU , Murat Özcan YAY , Hakan ÖZTÜRK , Çiğdem YENİSEY %T The effect of dexpanthenol on the formation of epidural fibrosis in an experimental laminectomy model in rats %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 1 %R doi: 10.28982/josam.597612 %U 10.28982/josam.597612
ISNAD KIZILAY, Zahir , KAHRAMAN ÇETİN, Nesibe , YAYCIOĞLU, Soner , YAY, Murat Özcan , ÖZTÜRK, Hakan , YENİSEY, Çiğdem . "The effect of dexpanthenol on the formation of epidural fibrosis in an experimental laminectomy model in rats". Journal of Surgery and Medicine 4 / 1 (January 2020): 16-20 . https://doi.org/10.28982/josam.597612
AMA KIZILAY Z , KAHRAMAN ÇETİN N , YAYCIOĞLU S , YAY M , ÖZTÜRK H , YENİSEY Ç . The effect of dexpanthenol on the formation of epidural fibrosis in an experimental laminectomy model in rats. J Surg Med. 2020; 4(1): 16-20.
Vancouver KIZILAY Z , KAHRAMAN ÇETİN N , YAYCIOĞLU S , YAY M , ÖZTÜRK H , YENİSEY Ç . The effect of dexpanthenol on the formation of epidural fibrosis in an experimental laminectomy model in rats. Journal of Surgery and Medicine. 2020; 4(1): 20-16.

Authors of the Article
Nesibe KAHRAMAN ÇETİN [2]
Soner YAYCIOĞLU [3]
Murat Özcan YAY [4]
Hakan ÖZTÜRK [5]
Çiğdem YENİSEY [6]